印度肠易激综合征和未经检查的消化不良患者中乳糜泻的患病率。

Prevalence of celiac disease in Indian patients with irritable bowel syndrome and uninvestigated dyspepsia.

作者信息

Sharma Hanish, Verma Anil K, Das Prasenjit, Dattagupta Siddhartha, Ahuja Vineet, Makharia Govind K

机构信息

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.

Pathology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Dig Dis. 2015 Aug;16(8):443-8. doi: 10.1111/1751-2980.12260.

DOI:10.1111/1751-2980.12260

PMID:25959064

Abstract

OBJECTIVE

The clinical spectrum of celiac disease (CeD) is wide and its symptoms overlap with those of functional bowel diseases. This study aimed to investigate the relationship among gluten-related disorders, irritable bowel syndrome (IBS) and uninvestigated dyspepsia in Indian patients.

METHODS

Patients with IBS and uninvestigated dyspepsia (using Rome III criteria) were tested for immunoglobulin A (IgA) anti-tissue transglutaminase (anti-tTG) antibody and anti-gliadin antibody (AGA). Those with positive anti-tTG antibody were evaluated for the presence of villous abnormalities. Patients who were only IgA AGA-positive were considered to have gluten sensitivity and those with positive anti-tTG antibody and villous atrophy were considered to have CeD.

RESULTS

Of 362 patients with IBS, 22 (6.1%) had positive anti-tTG antibody, among whom 3 (0.8%) had CeD and 19 had potential CeD. Of 358 patients with uninvestigated dyspepsia, 18 (5.0%) were anti-tTG antibody-positive and among them 4 (1.1%) had CeD and 14 had potential CeD. AGA was positive in 104 (28.7%) patients with IBS and 68 (19.0%) with uninvestigated dyspepsia, suggesting the presence of gluten sensitivity.

CONCLUSION

This study highlights the relationship between IBS or dyspepsia and CeD or gluten sensitivity.

摘要

目的

乳糜泻（CeD）的临床谱广泛，其症状与功能性肠病的症状重叠。本研究旨在调查印度患者中麸质相关疾病、肠易激综合征（IBS）和未经调查的消化不良之间的关系。

方法

对符合IBS和未经调查的消化不良（采用罗马III标准）的患者进行免疫球蛋白A（IgA）抗组织转谷氨酰胺酶（抗tTG）抗体和抗麦醇溶蛋白抗体（AGA）检测。抗tTG抗体阳性者评估是否存在绒毛异常。仅IgA AGA阳性的患者被认为患有麸质敏感性，抗tTG抗体阳性且有绒毛萎缩的患者被认为患有CeD。

结果

在362例IBS患者中，22例（6.1%）抗tTG抗体阳性，其中3例（0.8%）患有CeD，19例有潜在CeD。在358例未经调查的消化不良患者中，18例（5.0%）抗tTG抗体阳性，其中4例（1.1%）患有CeD，14例有潜在CeD。104例（28.7%）IBS患者和68例（19.0%）未经调查的消化不良患者AGA阳性，提示存在麸质敏感性。