Cochrane Stephen A, Lohans Christopher T, van Belkum Marco J, Bels Manon A, Vederas John C
Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, Alberta T6E 2M9, Canada.
Org Biomol Chem. 2015 Jun 7;13(21):6073-81. doi: 10.1039/c5ob00780a.
Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.
此前其他研究小组曾报道，多粘芽孢杆菌NRRL B - 30507可产生SRCAM 37，这是一种对空肠弯曲菌具有抗菌活性的IIA型细菌素。对该多粘芽孢杆菌菌株进行基因组测序并分离抗菌化合物后发现，其抗菌活性归因于多粘菌素和十三肽菌素B1。本文报道了十三肽菌素B1的完整结构鉴定、合成及其抗菌谱，以及负责其生物合成的假定基因簇。该肽对多重耐药革兰氏阴性菌显示出强大活性，这一发现对于当前的抗生素耐药性问题而言正逢其时。
