Ferretti Yuri, Miyoshi Newton Shydeo Brandão, Silva Wilson Araújo, Felipe Joaquim Cezar
Inter-institutional Post-graduation Program on Bioinformatics, University of São Paulo, Brazil; Department of Computing and Mathematics, Faculty of Philosophy Sciences and Languages of Ribeirão Preto, University of São Paulo, Brazil.
Inter-institutional Post-graduation Program on Bioinformatics, University of São Paulo, Brazil.
Comput Biol Med. 2017 May 1;84:254-261. doi: 10.1016/j.compbiomed.2015.04.008. Epub 2015 Apr 15.
Researchers of translational medicine face numerous challenges in attempting to bring research results to the bedside. This field of research covers a wide range of resources, including blood and tissue samples, which are processed for isolation of RNA and DNA to study cancer omics data (genomics, proteomics and metabolomics). Clinical information about patients׳ habits, family history, physical examinations, remissions, etc., is also important to underpin studies aimed at identifying patterns that lead to the development of cancer and to its successful treatment.
Development of a web-based computer system-BioBankWarden-to manage, consolidate and integrate these diversified data, enabling cancer research groups to retrieve and analyze clinical and biomolecular data within an integrative environment. The system has a three-tier architecture comprising database, logic and user-interface layers.
The system׳s integrated database and user-friendly interface allow for the control of patient records, biomaterial storage, research groups, research projects, users and biomaterial exchange.
BioBankWarden can be used to store and retrieve specific information from different clinical fields linked to biomaterials collected from patients, providing the functionalities required to support translational research in the field of cancer.
转化医学研究人员在尝试将研究成果应用于临床时面临诸多挑战。该研究领域涵盖广泛的资源，包括血液和组织样本，这些样本经过处理以分离RNA和DNA，用于研究癌症组学数据（基因组学、蛋白质组学和代谢组学）。有关患者习惯、家族病史、体格检查、缓解情况等的临床信息对于支持旨在识别导致癌症发生及其成功治疗的模式的研究也很重要。
开发一个基于网络的计算机系统——生物样本库管理员（BioBankWarden），以管理、整合和集成这些多样化的数据，使癌症研究团队能够在一个整合的环境中检索和分析临床及生物分子数据。该系统具有包含数据库、逻辑和用户界面层的三层架构。
该系统的集成数据库和用户友好界面允许对患者记录、生物材料存储、研究团队、研究项目、用户和生物材料交换进行管理。
生物样本库管理员（BioBankWarden）可用于存储和检索与从患者收集的生物材料相关的不同临床领域的特定信息，提供支持癌症领域转化研究所需的功能。
