Luo Yunzi, Li Bing-Zhi, Liu Duo, Zhang Lu, Chen Yan, Jia Bin, Zeng Bo-Xuan, Zhao Huimin, Yuan Ying-Jin
Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, P. R. China.
Chem Soc Rev. 2015 Aug 7;44(15):5265-90. doi: 10.1039/c5cs00025d. Epub 2015 May 11.
Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.
由微生物和植物产生的天然产物是抗菌和抗癌药物以及工业上有用化合物的主要来源。然而，天然生产者往往产量低、滴度低。在这里，我们总结了异源生物合成在生产几类重要天然产物（如萜类化合物、黄酮类化合物、生物碱和聚酮化合物）方面的最新应用。此外，我们还将讨论在基因、途径、基因组和群落水平等多尺度层面上用于天然产物高效异源生物合成的新工具和策略。
