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Microbial biosynthesis of medicinally important plant secondary metabolites.
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Engineering non-P450 3-hydroxylase for synthesizes catechol-containing compounds in .
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Nepeta cataria L. (catnip) can serve as a chassis for the engineering of secondary metabolic pathways.
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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2847-52. doi: 10.1073/pnas.1419028112. Epub 2015 Feb 17.
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Distributing a metabolic pathway among a microbial consortium enhances production of natural products.
Nat Biotechnol. 2015 Apr;33(4):377-83. doi: 10.1038/nbt.3095. Epub 2015 Jan 5.
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Rapid prototyping of microbial cell factories via genome-scale engineering.
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Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways.
Microb Cell Fact. 2014 Nov 18;13:160. doi: 10.1186/s12934-014-0160-x.
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Recent advances in natural product discovery.
Curr Opin Biotechnol. 2014 Dec;30:230-7. doi: 10.1016/j.copbio.2014.09.002. Epub 2014 Sep 26.
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Homology-integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae.
ACS Synth Biol. 2015 May 15;4(5):585-94. doi: 10.1021/sb500255k. Epub 2014 Sep 19.
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Natural product and natural product derived drugs in clinical trials.
Nat Prod Rep. 2014 Nov;31(11):1612-61. doi: 10.1039/c4np00064a.
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Total synthesis of a eukaryotic chromosome: Redesigning and SCRaMbLE-ing yeast.
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