Zhang Yang, Cheng Cheng, Fu Bixia, Long Teng, He Ning, Fan Jianqiang, Xue Zheyong, Chen Anqi, Yuan Jifeng
School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian 361102, China.
Technology Center, China Tobacco Fujian Industrial Co. Ltd., Xiamen 361000, Fujian, China.
Biodes Res. 2024 Jan 22;6:0027. doi: 10.34133/bdr.0027. eCollection 2024.
Lignin is one of the most widespread organic compounds found on earth, boasting a wealth of aromatic molecules. The use of lignin feedstock for biochemical productions is of great importance for achieving "carbon neutrality." In recent years, a strategy for lignin valorization known as the "bio-funnel" has been proposed as a means to generate a variety of commercially valuable chemicals from lignin-derived compounds. The implementation of biocatalysis and metabolic engineering techniques has substantially advanced the biotransformation of depolymerized lignin into chemicals and materials within the supply chain. In this review, we present an overview of the latest advancements in microbial upcycling of depolymerized lignin into value-added chemicals. Besides, the review provides insights into the problems facing current biological lignin valorization while proposing further research directions to improve these technologies for the extensive accomplishment of the lignin upcycling.
木质素是地球上分布最广泛的有机化合物之一，含有大量芳香分子。将木质素原料用于生物化学产品生产对于实现“碳中和”至关重要。近年来，一种名为“生物漏斗”的木质素增值策略被提出来，作为从木质素衍生化合物中生成各种具有商业价值化学品的一种手段。生物催化和代谢工程技术的应用极大地推动了供应链中解聚木质素向化学品和材料的生物转化。在本综述中，我们概述了将解聚木质素微生物转化为增值化学品的最新进展。此外，该综述深入探讨了当前生物木质素增值面临的问题，同时提出了进一步的研究方向，以改进这些技术，从而广泛实现木质素的循环利用。
