Di Maso Matteo, Bosetti Cristina, La Vecchia Carlo, Garavello Werner, Montella Maurizio, Libra Massimo, Serraino Diego, Polesel Jerry
Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy.
Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
Cancer Epidemiol. 2015 Aug;39(4):545-7. doi: 10.1016/j.canep.2015.04.012. Epub 2015 May 8.
Regular aspirin use has been associated to decreased risk of several cancers, but evidence on nasopharyngeal carcinoma is scanty. We conducted a hospital-based case-control study in Italy, enrolling 198 Caucasian patients with nasopharyngeal carcinoma. Controls were 592 cancer-free Caucasian patients admitted to the same catchment areas as cases; controls were frequency matched according to sex, age, and area of residence. Regular aspirin use was defined as taking at least one aspirin a week for at least 6 months. Three cases (1.5%) and 27 controls (4.5%) reported regular aspirin use (odds ratio=0.24; 95% CI: 0.07-0.87). The median duration of consumption was 15 months among cases and 60 months among controls. Although study findings should be considered with caution due to limited sample size, they provide further evidence on the protective effect of aspirin use in head and neck cancers.
长期服用阿司匹林与多种癌症风险降低有关，但关于鼻咽癌的证据却很少。我们在意大利进行了一项基于医院的病例对照研究，招募了198名患有鼻咽癌的白种人患者。对照组为592名与病例来自相同集水区的无癌白种人患者；对照组根据性别、年龄和居住地区进行频率匹配。定期服用阿司匹林的定义为每周至少服用一片阿司匹林，且持续至少6个月。3例患者（1.5%）和27名对照者（4.5%）报告有定期服用阿司匹林（比值比=0.24；95%置信区间：0.07-0.87）。病例组的中位服用时长为15个月，对照组为60个月。尽管由于样本量有限，研究结果应谨慎看待，但它们为阿司匹林在头颈部癌症中的保护作用提供了进一步的证据。
