Shi Jun, Leng Weidong, Zhao Lunhua, Xu Chenli, Wang Jue, Chen Xiaoli, Wang Yu, Peng Xingchun
Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.
School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei, 442000, China.
Oncotarget. 2017 Oct 5;8(58):99066-99074. doi: 10.18632/oncotarget.21524. eCollection 2017 Nov 17.
Conflicting results identifying the relationship between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk. Therefore, we performed this meta-analysis to clarify and quantitative assessed the relationship between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk. Up to March 2017, 11 original publications were included in this meta-analysis. Our results showed statistically significant association between nonsteroidal anti-inflammatory drugs using and head and neck cancer risk reduction. Subgroups analysis indicated that Aspirin, COX 2 inhibitors, Ibuprofen and Other NSAIDs were associated with a significantly risk reduction of head and neck cancer. Furthermore, nonsteroidal anti-inflammatory drugs using was associated with a significantly lower risk of oral and oropharynx cancer, larynx cancer and hypopharynx cancer. In addition, increasing nonsteroidal anti-inflammatory drugs using (per 2 prescriptions/week increment) was associated with a 4% reduction in head and neck cancer risk, 5% reduction of aspirin using and 6% reduction of other nonsteroidal anti-inflammatory drugs using. Considering these promising results, increasing nonsteroidal anti-inflammatory drugs using might provide health benefits. More studies and large sample size are warranted to validate this association.
关于非甾体抗炎药的使用与头颈癌风险之间的关系，研究结果存在冲突。因此，我们进行了这项荟萃分析，以阐明并定量评估非甾体抗炎药的使用与头颈癌风险之间的关系。截至2017年3月，共有11篇原始文献纳入了这项荟萃分析。我们的结果显示，非甾体抗炎药的使用与头颈癌风险降低之间存在统计学上的显著关联。亚组分析表明，阿司匹林、COX-2抑制剂、布洛芬和其他非甾体抗炎药与头颈癌风险的显著降低相关。此外，使用非甾体抗炎药与口腔和口咽癌、喉癌和下咽癌的风险显著降低相关。另外，非甾体抗炎药使用量增加（每增加2张处方/周）与头颈癌风险降低4%、阿司匹林使用量降低5%以及其他非甾体抗炎药使用量降低6%相关。鉴于这些有前景的结果，增加非甾体抗炎药的使用可能对健康有益。需要更多研究和大样本量来验证这种关联。
