Kim Bun, Park Soo Jung, Hong Sung Pil, Cheon Jae Hee, Kim Tae Il, Kim Won Ho
Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Gut Liver. 2015 Nov 23;9(6):750-5. doi: 10.5009/gnl14193.
BACKGROUND/AIMS: Anemia in patients with inflammatory bowel disease significantly affects the quality of life. The aim of this study was to investigate the frequency of and risk factors for anemia and to describe the management of anemia in patients with intestinal Behçet's disease (BD) in actual clinical practice.
We included 64 patients with intestinal BD who visited the outpatient clinic of a tertiary referral center in June 2011 and had available laboratory data for the subsequent 6 months.
Anemia was detected in 26 patients (40.6%). After 6 months, anemia was still present in 14 of these patients (53.8%). The cause of anemia was investigated in eight patients (30.8%), and oral iron supplementation was prescribed to four patients (15.4%). Of these four patients, two (50%) recovered completely within 6 months. Anemia was associated with a high Disease Activity Index for Intestinal Behçet's Disease (DAIBD, p=0.024), erythrocyte sedimentation rate (p=0.003), and C-reactive protein (p=0.049) in univariate analysis. In multivariate analysis, the factor predictive for anemia in patients with intestinal BD was a higher DAIBD (≥40; odds ratio, 4.08; 95% confidence interval, 1.21 to 13.71; p=0.023).
Although anemia is common in intestinal BD patients, its clinical importance is overlooked in daily practice. Moderate to severe disease activity is predictive of anemia.
背景/目的：炎症性肠病患者的贫血显著影响生活质量。本研究旨在调查肠道白塞病（BD）患者贫血的发生率和危险因素，并描述实际临床实践中肠道白塞病患者贫血的管理情况。
我们纳入了2011年6月就诊于一家三级转诊中心门诊且在随后6个月有可用实验室数据的64例肠道BD患者。
26例患者（40.6%）检测到贫血。6个月后，其中14例患者（53.8%）仍存在贫血。对8例患者（30.8%）的贫血原因进行了调查，4例患者（15.4%）接受了口服铁剂补充治疗。在这4例患者中，2例（50%）在6个月内完全康复。单因素分析显示，贫血与肠道白塞病疾病活动指数（DAIBD，p=0.024）、红细胞沉降率（p=0.003）和C反应蛋白（p=0.049）升高有关。多因素分析显示预测肠道BD患者贫血的因素是较高的DAIBD（≥40；比值比，4.08；95%置信区间，1.21至13.71；p=0.023）。
虽然贫血在肠道BD患者中很常见，但在日常实践中其临床重要性被忽视。中度至重度疾病活动是贫血的预测因素。
