TRPM2的激活剂：正确理解它 - Suppr

Activators of TRPM2: Getting it right.

作者信息

Rosenbaum Tamara

机构信息

Departamento de Neurodesarrollo y Fisiología, División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México D.F., México

出版信息

J Gen Physiol. 2015 Jun;145(6):485-7. doi: 10.1085/jgp.201511405. Epub 2015 May 11.

DOI:10.1085/jgp.201511405

PMID:25964430

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4442784/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d92e/4442784/7a2087cd40b5/JGP_201511405_Fig1.jpg

相似文献

Activators of TRPM2: Getting it right.TRPM2的激活剂：正确理解它

J Gen Physiol. 2015 Jun;145(6):485-7. doi: 10.1085/jgp.201511405. Epub 2015 May 11.

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate.排除吡啶二核苷酸作为真正的TRPM2通道激活剂，揭示了新型直接激动剂2'-磷酸-ADP-核糖。

J Gen Physiol. 2015 May;145(5):419-30. doi: 10.1085/jgp.201511377.

Response to ADP-ribose by activation of TRPM2 in the CRI-G1 insulinoma cell line.CRI-G1胰岛素瘤细胞系中通过激活TRPM2对ADP-核糖的反应。

J Membr Biol. 2003 Feb 1;191(3):201-7. doi: 10.1007/s00232-002-1057-x.

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase.瞬时受体电位阳离子通道蛋白2（TRPM2）通道对氧化应激的开放依赖于聚（ADP-核糖）聚合酶的激活。

Br J Pharmacol. 2004 Sep;143(1):186-92. doi: 10.1038/sj.bjp.0705914. Epub 2004 Aug 9.

TRPM2 activation: Paradigm shifted?TRPM2 的激活：范式转变？

Cell Calcium. 2018 Dec;76:132-134. doi: 10.1016/j.ceca.2018.11.001. Epub 2018 Nov 3.

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain.ADP-核糖独立于NUDT9H结构域激活海葵星状海葵的TRPM2通道。

PLoS One. 2016 Jun 22;11(6):e0158060. doi: 10.1371/journal.pone.0158060. eCollection 2016.

It takes two to Tango: Two gates orchestrate the opening of human TRPM2.需要两个人来跳探戈：两个门控协同开启人类 TRPM2。

Cell Calcium. 2022 Jan;101:102523. doi: 10.1016/j.ceca.2021.102523. Epub 2021 Dec 23.

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones.重组大鼠TRPM2及培养的大鼠纹状体神经元中类似TRPM2的电导特性

Neuropharmacology. 2006 Jan;50(1):89-97. doi: 10.1016/j.neuropharm.2005.08.021. Epub 2005 Nov 2.

Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes.内源性ADP-核糖可通过中性粒细胞中的TRPM2通道实现钙调节阳离子电流。

Biochem J. 2006 Sep 1;398(2):225-32. doi: 10.1042/BJ20060183.

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium.三磷酸腺苷二核糖和钙诱导瞬时受体电位 M2 通道激活的进化轨迹。

Sci Bull (Beijing). 2024 Sep 30;69(18):2892-2905. doi: 10.1016/j.scib.2024.04.052. Epub 2024 Apr 26.

引用本文的文献

Roles of TRPM channels in glioma.TRPM 通道在神经胶质瘤中的作用。

Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.

Pathological Mechanisms Induced by TRPM2 Ion Channels Activation in Renal Ischemia-Reperfusion Injury.TRPM2 离子通道激活在肾缺血再灌注损伤中的病理机制。

Mol Biol Rep. 2022 Nov;49(11):11071-11079. doi: 10.1007/s11033-022-07836-w. Epub 2022 Sep 14.

Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine".高热与血清素：寻找“更好的赛庚啶”。

Int J Mol Sci. 2022 Mar 20;23(6):3365. doi: 10.3390/ijms23063365.

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR).第二信使5'-二磷酸腺苷核糖（ADPR）的膦酰乙酸类似物的合成。

RSC Adv. 2020;10(3):1776-1785. doi: 10.1039/C9RA09284F. Epub 2020 Jan 9.

HIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor?HIV 疾病进展：外切酶 CD38 的过表达是否是一个促成因素？

Bioessays. 2019 Jan;41(1):e1800128. doi: 10.1002/bies.201800128. Epub 2018 Dec 10.

本文引用的文献

J Gen Physiol. 2015 May;145(5):419-30. doi: 10.1085/jgp.201511377.

Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating.TRPM2阳离子通道的假定通道酶活性与孔道门控无关。

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16949-54. doi: 10.1073/pnas.1412449111. Epub 2014 Nov 10.

TRPM2: a multifunctional ion channel for calcium signalling.瞬时受体电位阳离子通道 M2 亚型：钙信号的多功能离子通道。

J Physiol. 2011 Apr 1;589(Pt 7):1515-25. doi: 10.1113/jphysiol.2010.201855. Epub 2010 Dec 6.

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.鉴定瞬时受体电位 melastatin 2 (TRPM2)阳离子通道的直接和间接效应物。

J Biol Chem. 2010 Sep 24;285(39):30091-102. doi: 10.1074/jbc.M109.066464. Epub 2010 Jul 22.

Requirement for the N-terminal coiled-coil domain for expression and function, but not subunit interaction of, the ADPR-activated TRPM2 channel.ADPR 激活的 TRPM2 通道的表达和功能对 N 端卷曲螺旋结构域有需求，但对亚基相互作用无需求。

J Membr Biol. 2009 Jul;230(2):93-9. doi: 10.1007/s00232-009-9190-4. Epub 2009 Aug 5.

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate.四个钙离子通过结合在靠近孔道但位于门控结构细胞内侧的深裂缝中来激活TRPM2通道。

J Gen Physiol. 2009 Feb;133(2):189-203. doi: 10.1085/jgp.200810109.

On the nature of partial agonism in the nicotinic receptor superfamily.论烟碱样受体超家族中部分激动剂的性质。

Nature. 2008 Aug 7;454(7205):722-7. doi: 10.1038/nature07139. Epub 2008 Jul 16.

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils.腺嘌呤二核苷酸对原代人中性粒细胞内源性TRPM2通道的协同调节作用

Cell Calcium. 2008 Dec;44(6):604-15. doi: 10.1016/j.ceca.2008.05.001. Epub 2008 Jun 24.

A calcium influx pathway regulated separately by oxidative stress and ADP-Ribose in TRPM2 channels: single channel events.TRPM2通道中由氧化应激和ADP-核糖分别调节的钙内流途径：单通道事件

Neurochem Res. 2008 Jul;33(7):1256-62. doi: 10.1007/s11064-007-9577-5. Epub 2008 Feb 8.

Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes.烟酰胺腺嘌呤二核苷酸磷酸和环二磷酸腺苷核糖调节T淋巴细胞中的TRPM2通道。

FASEB J. 2006 May;20(7):962-4. doi: 10.1096/fj.05-5538fje. Epub 2006 Apr 3.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Activators of TRPM2: Getting it right.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献