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Activators of TRPM2: Getting it right.

作者信息

Rosenbaum Tamara

机构信息

Departamento de Neurodesarrollo y Fisiología, División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México D.F., México

出版信息

J Gen Physiol. 2015 Jun;145(6):485-7. doi: 10.1085/jgp.201511405. Epub 2015 May 11.

DOI:10.1085/jgp.201511405
PMID:25964430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4442784/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d92e/4442784/dadc1338ab57/JGP_201511405_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d92e/4442784/7a2087cd40b5/JGP_201511405_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d92e/4442784/dadc1338ab57/JGP_201511405_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d92e/4442784/7a2087cd40b5/JGP_201511405_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d92e/4442784/dadc1338ab57/JGP_201511405_Fig2.jpg

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本文引用的文献

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Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate.排除吡啶二核苷酸作为真正的TRPM2通道激活剂，揭示了新型直接激动剂2'-磷酸-ADP-核糖。
J Gen Physiol. 2015 May;145(5):419-30. doi: 10.1085/jgp.201511377.
2
Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating.TRPM2阳离子通道的假定通道酶活性与孔道门控无关。
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16949-54. doi: 10.1073/pnas.1412449111. Epub 2014 Nov 10.
3
TRPM2: a multifunctional ion channel for calcium signalling.
Int J Mol Sci. 2022 Mar 20;23(6):3365. doi: 10.3390/ijms23063365.
4
Synthesis of phosphonoacetate analogues of the second messenger adenosine 5'-diphosphate ribose (ADPR).第二信使5'-二磷酸腺苷核糖（ADPR）的膦酰乙酸类似物的合成。
RSC Adv. 2020;10(3):1776-1785. doi: 10.1039/C9RA09284F. Epub 2020 Jan 9.
5
HIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor?HIV 疾病进展：外切酶 CD38 的过表达是否是一个促成因素？
Bioessays. 2019 Jan;41(1):e1800128. doi: 10.1002/bies.201800128. Epub 2018 Dec 10.
瞬时受体电位阳离子通道 M2 亚型：钙信号的多功能离子通道。
J Physiol. 2011 Apr 1;589(Pt 7):1515-25. doi: 10.1113/jphysiol.2010.201855. Epub 2010 Dec 6.
4
Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.鉴定瞬时受体电位 melastatin 2 (TRPM2)阳离子通道的直接和间接效应物。
J Biol Chem. 2010 Sep 24;285(39):30091-102. doi: 10.1074/jbc.M109.066464. Epub 2010 Jul 22.
5
Requirement for the N-terminal coiled-coil domain for expression and function, but not subunit interaction of, the ADPR-activated TRPM2 channel.ADPR 激活的 TRPM2 通道的表达和功能对 N 端卷曲螺旋结构域有需求，但对亚基相互作用无需求。
J Membr Biol. 2009 Jul;230(2):93-9. doi: 10.1007/s00232-009-9190-4. Epub 2009 Aug 5.
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J Gen Physiol. 2009 Feb;133(2):189-203. doi: 10.1085/jgp.200810109.
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On the nature of partial agonism in the nicotinic receptor superfamily.论烟碱样受体超家族中部分激动剂的性质。
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Neurochem Res. 2008 Jul;33(7):1256-62. doi: 10.1007/s11064-007-9577-5. Epub 2008 Feb 8.
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Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes.烟酰胺腺嘌呤二核苷酸磷酸和环二磷酸腺苷核糖调节T淋巴细胞中的TRPM2通道。
FASEB J. 2006 May;20(7):962-4. doi: 10.1096/fj.05-5538fje. Epub 2006 Apr 3.