探索环境性肠病在营养不良、婴儿发育及口服疫苗反应中的作用。
Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response.
作者信息
Gilmartin Allissia A, Petri William A
机构信息
Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
出版信息
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0143.
Abstract
Environmental enteropathy (EE) is a poorly defined state of intestinal inflammation without overt diarrhoea that occurs in individuals exposed over time to poor sanitation and hygiene. It is characterized pathologically by small intestine villous blunting and inflammation. In children from low-income countries, it is implicated as a cause of malnutrition, oral vaccine failure and impaired cognitive development. Here we review the search for non-invasive biomarkers to measure EE non-invasively, and assess the current evidence linking EE to malnutrition, vaccine failure and neurocognitive development.
摘要
环境肠病（EE）是一种定义不明确的肠道炎症状态，无明显腹泻，发生在长期暴露于卫生条件差和卫生习惯不良环境中的个体。其病理特征为小肠绒毛变钝和炎症。在低收入国家的儿童中，它被认为是营养不良、口服疫苗失效和认知发育受损的一个原因。在此，我们综述了寻找非侵入性生物标志物以无创测量环境肠病的研究，并评估了目前将环境肠病与营养不良、疫苗失效和神经认知发育联系起来的证据。
相似文献
1
Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response.探索环境性肠病在营养不良、婴儿发育及口服疫苗反应中的作用。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0143.
2
Environmental Enteropathy, Oral Vaccine Failure and Growth Faltering in Infants in Bangladesh.孟加拉国婴儿的环境肠病、口服疫苗失败和生长迟缓。
EBioMedicine. 2015 Sep 25;2(11):1759-66. doi: 10.1016/j.ebiom.2015.09.036. eCollection 2015 Nov.
3
Environmental enteropathy and malnutrition: do we know enough to intervene?环境性肠病与营养不良：我们是否了解足够可进行干预？
BMC Med. 2014 Oct 14;12:187. doi: 10.1186/s12916-014-0187-1.
4
Environmental enteropathy and its association with water sanitation and hygiene in slum areas of Jimma Town Ethiopia.埃塞俄比亚吉姆马镇贫民窟环境卫生差与环境卫生和个人卫生措施不足有关。
PLoS One. 2023 Jun 23;18(6):e0286866. doi: 10.1371/journal.pone.0286866. eCollection 2023.
5
Causes of impaired oral vaccine efficacy in developing countries.发展中国家口腔疫苗效力受损的原因。
Future Microbiol. 2018 Jan;13(1):97-118. doi: 10.2217/fmb-2017-0128. Epub 2017 Dec 8.
6
Environmental Enteropathy: Elusive but Significant Subclinical Abnormalities in Developing Countries.环境性肠病：发展中国家难以捉摸但意义重大的亚临床异常。
EBioMedicine. 2016 Aug;10:25-32. doi: 10.1016/j.ebiom.2016.07.030. Epub 2016 Jul 26.
7
Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework.MAL-ED队列研究中环境肠病的评估：理论与分析框架
Clin Infect Dis. 2014 Nov 1;59 Suppl 4(Suppl 4):S239-47. doi: 10.1093/cid/ciu457.
8
Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children.环境性肠病的生物标志物与孟加拉国儿童口服霍乱疫苗的免疫反应呈正相关。
PLoS Negl Trop Dis. 2016 Nov 8;10(11):e0005039. doi: 10.1371/journal.pntd.0005039. eCollection 2016 Nov.
9
Intestinal Biopsies for the Evaluation of Environmental Enteropathy and Environmental Enteric Dysfunction.用于评估环境肠病和环境肠功能障碍的肠道活检。
J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S856-S863. doi: 10.1093/infdis/jiab372.
10
Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy.环境肠道功能障碍的病理生理学及其对口服疫苗效力的影响。
Mucosal Immunol. 2018 Sep;11(5):1290-1298. doi: 10.1038/s41385-018-0036-1. Epub 2018 Jul 9.
引用本文的文献
1
Blades and barriers: Oral vaccines for conquering cancers and warding off infectious diseases.利刃与屏障：用于攻克癌症和抵御传染病的口服疫苗
Acta Pharm Sin B. 2025 Aug;15(8):3925-3950. doi: 10.1016/j.apsb.2025.05.038. Epub 2025 Jun 3.
2
Global acute malnutrition is associated with geography, season and malaria incidence in the conflict-affected regions of Ouham and Ouham Pendé prefectures, Central African Republic.全球急性营养不良与中非共和国瓦姆省和瓦姆-彭代省受冲突影响地区的地理位置、季节和疟疾发病率有关。
BMC Med. 2024 Sep 11;22(1):380. doi: 10.1186/s12916-024-03603-9.
3
Cellular and molecular basis of proximal small intestine disorders.近端小肠疾病的细胞和分子基础。
Nat Rev Gastroenterol Hepatol. 2024 Oct;21(10):687-709. doi: 10.1038/s41575-024-00962-9. Epub 2024 Aug 8.
4
Factors associated with stunting in under-five children with environmental enteropathy in slum areas of Jimma town, Ethiopia.埃塞俄比亚吉姆马镇贫民窟地区患有环境肠病的五岁以下儿童发育迟缓的相关因素。
Front Nutr. 2024 Apr 8;11:1335961. doi: 10.3389/fnut.2024.1335961. eCollection 2024.
5
Do 4 and long COVID-19 increase the risk for neurodegenerative diseases in adverse environments and poverty?4 型糖尿病和长期新冠病毒感染是否会在不利环境和贫困状况下增加患神经退行性疾病的风险？
Front Neurosci. 2023 Aug 24;17:1229073. doi: 10.3389/fnins.2023.1229073. eCollection 2023.
6
Environmental enteropathy and its association with water sanitation and hygiene in slum areas of Jimma Town Ethiopia.埃塞俄比亚吉姆马镇贫民窟环境卫生差与环境卫生和个人卫生措施不足有关。
PLoS One. 2023 Jun 23;18(6):e0286866. doi: 10.1371/journal.pone.0286866. eCollection 2023.
7
Essential Fatty Acid Deficiency Associates with Growth Faltering and Environmental Enteric Dysfunction in Children.必需脂肪酸缺乏与儿童生长发育迟缓及环境性肠道功能障碍相关。
Metabolites. 2023 Mar 29;13(4):489. doi: 10.3390/metabo13040489.
8
The prevalence of intestinal parasites, undernutrition and their associated risk factors among school-age children in Sekota Town, Northeast Ethiopia: A community-based cross-sectional study.埃塞俄比亚东北部塞科塔镇学龄儿童肠道寄生虫感染率、营养不良状况及其相关危险因素：一项基于社区的横断面研究。
Health Sci Rep. 2023 Feb 26;6(3):e1137. doi: 10.1002/hsr2.1137. eCollection 2023 Mar.
9
Ready-to-Use Therapeutic Foods Fail to Improve Vitamin A and Iron Status Meaningfully during Treatment for Severe Acute Malnutrition in 6-59-Month-old Cambodian Children.在柬埔寨 6-59 月龄儿童严重急性营养不良治疗期间，即食治疗性食品未能显著改善维生素 A 和铁的状况。
Nutrients. 2023 Feb 10;15(4):905. doi: 10.3390/nu15040905.
10
Astrocytes and Microglia in Stress-Induced Neuroinflammation: The African Perspective.应激诱导的神经炎症中的星形胶质细胞和小胶质细胞：非洲视角。
Front Immunol. 2022 May 30;13:795089. doi: 10.3389/fimmu.2022.795089. eCollection 2022.
本文引用的文献
1
Environmental enteropathy and malnutrition: do we know enough to intervene?环境性肠病与营养不良：我们是否了解足够可进行干预？
BMC Med. 2014 Oct 14;12:187. doi: 10.1186/s12916-014-0187-1.
2
Pediatric small intestine bacterial overgrowth in low-income countries.低收入国家的小儿小肠细菌过度生长
Trends Mol Med. 2015 Jan;21(1):6-15. doi: 10.1016/j.molmed.2014.11.001. Epub 2014 Nov 15.
3
Multiple micronutrient supplementation transiently ameliorates environmental enteropathy in Malawian children aged 12-35 months in a randomized controlled clinical trial.在一项随机对照临床试验中，补充多种微量营养素可短暂改善12至35个月大马拉维儿童的环境性肠病。
J Nutr. 2014 Dec;144(12):2059-65. doi: 10.3945/jn.114.201673. Epub 2014 Oct 1.
4
Environmental enteric dysfunction: pathogenesis, diagnosis, and clinical consequences.环境性肠功能障碍：发病机制、诊断及临床后果
Clin Infect Dis. 2014 Nov 1;59 Suppl 4(Suppl 4):S207-12. doi: 10.1093/cid/ciu485.
5
The intestinal microbiome in early life: health and disease.生命早期的肠道微生物组：健康与疾病。
Front Immunol. 2014 Sep 5;5:427. doi: 10.3389/fimmu.2014.00427. eCollection 2014.
6
Influence of enteric infections on response to oral poliovirus vaccine: a systematic review and meta-analysis.肠内感染对口服脊髓灰质炎疫苗反应的影响：系统评价和荟萃分析。
J Infect Dis. 2014 Sep 15;210(6):853-64. doi: 10.1093/infdis/jiu182. Epub 2014 Mar 31.
7
Stunting is characterized by chronic inflammation in Zimbabwean infants.在津巴布韦婴儿中，发育迟缓的特征是慢性炎症。
PLoS One. 2014 Feb 18;9(2):e86928. doi: 10.1371/journal.pone.0086928. eCollection 2014.
8
Febrile illness and pro-inflammatory cytokines are associated with lower neurodevelopmental scores in Bangladeshi infants living in poverty.发热性疾病和促炎细胞因子与孟加拉国贫困地区生活的婴儿的神经发育评分较低有关。
BMC Pediatr. 2014 Feb 18;14:50. doi: 10.1186/1471-2431-14-50.
9
Rotavirus vaccines: successes and challenges.轮状病毒疫苗：成功与挑战。
J Infect. 2014 Jan;68 Suppl 1:S9-18. doi: 10.1016/j.jinf.2013.09.010. Epub 2013 Oct 22.
10
Etiology of diarrhea in Bangladeshi infants in the first year of life analyzed using molecular methods.采用分子方法分析孟加拉国婴儿生命第一年腹泻的病因。
J Infect Dis. 2013 Dec 1;208(11):1794-802. doi: 10.1093/infdis/jit507. Epub 2013 Sep 16.
Zotero 插件