影响婴儿期先天免疫和疫苗反应的因素。
Factors influencing innate immunity and vaccine responses in infancy.
作者信息
Kampmann Beate, Jones Christine E
机构信息
Vaccines and Immunity Theme, MRC Unit, The Gambia, Atlantic Road, Fajara, The Gambia Academic Department of Paediatrics, Imperial College London, Norfolk Place, London, UK
Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St George's, University of London, Cranmer Terrace, London, UK.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0148.
Abstract
Despite significant progress in reducing the burden of mortality in children under the age of five, reducing mortality in newborns remains a major challenge. Infection plays a significant role in infant deaths and interventions such as early vaccination or antenatal immunization could make a significant contribution to prevention of such deaths. In the last few years, we have gained new insights into immune ontogeny and are now beginning to understand the impact of vaccines, nutrition and environmental factors on 'training' of the immune response in early life. This review article sets out to explain why vaccine responses can be heterogeneous between populations and individuals by providing examples chosen to illustrate the impact of host, pathogen and environmental factors on shaping the immune 'interactome' in young children.
摘要
尽管在降低五岁以下儿童的死亡负担方面取得了重大进展，但降低新生儿死亡率仍然是一项重大挑战。感染在婴儿死亡中起着重要作用，早期疫苗接种或产前免疫等干预措施对预防此类死亡可做出重大贡献。在过去几年中，我们对免疫个体发生有了新的认识，现在开始了解疫苗、营养和环境因素对生命早期免疫反应“训练”的影响。这篇综述文章旨在通过提供一些例子来解释为什么不同人群和个体之间的疫苗反应可能存在差异，这些例子旨在说明宿主、病原体和环境因素对塑造幼儿免疫“相互作用组”的影响。
相似文献
1
Factors influencing innate immunity and vaccine responses in infancy.影响婴儿期先天免疫和疫苗反应的因素。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0148.
2
Immune response to vaccine adjuvants during the first year of life.婴儿期第一年的疫苗佐剂免疫应答。
Vaccine. 2013 May 17;31(21):2500-5. doi: 10.1016/j.vaccine.2012.10.016. Epub 2012 Oct 18.
3
Vaccine responses in newborns.新生儿的疫苗反应。
Semin Immunopathol. 2017 Nov;39(6):627-642. doi: 10.1007/s00281-017-0654-9. Epub 2017 Nov 9.
4
Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation .人类新生儿单核细胞表现出不同的 BCG 诱导的原发性和训练性固有细胞因子产生和代谢激活。
Front Immunol. 2021 Jul 13;12:674334. doi: 10.3389/fimmu.2021.674334. eCollection 2021.
5
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: neonatal immune function and vaccine responses in children born in low-income versus high-income countries.第 99 届达勒姆感染、炎症和慢性炎症性疾病会议：在低收入和高收入国家出生的儿童的新生儿免疫功能和疫苗反应。
Clin Exp Immunol. 2010 Apr;160(1):42-7. doi: 10.1111/j.1365-2249.2010.04137.x.
6
The impact of vaccines on heterologous adaptive immunity.疫苗对异源适应性免疫的影响。
Clin Microbiol Infect. 2019 Dec;25(12):1484-1493. doi: 10.1016/j.cmi.2019.02.016. Epub 2019 Feb 20.
7
Ontogeny of Toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants. Papua New Guinean 婴儿中 Toll 样和 NOD 样受体介导的先天免疫反应的个体发生。
PLoS One. 2012;7(5):e36793. doi: 10.1371/journal.pone.0036793. Epub 2012 May 23.
8
Vaccine-induced antibody responses as parameters of the influence of endogenous and environmental factors.疫苗诱导的抗体反应作为内源性和环境因素影响的参数。
Environ Health Perspect. 2001 Aug;109(8):757-64. doi: 10.1289/ehp.01109757.
9
The challenge of assessing infant vaccine responses in resource-poor settings.在资源匮乏的环境下评估婴儿疫苗反应的挑战。
Expert Rev Vaccines. 2010 Jun;9(6):665-74. doi: 10.1586/erv.10.41.
10
Heterologous Effects of Pertussis and Influenza Vaccines During Pregnancy on Maternal and Infant Innate Immune Responses: A Pilot Study.孕期百日咳疫苗和流感疫苗对母婴先天免疫反应的异源效应：一项试点研究。
Pediatr Infect Dis J. 2025 Feb 1;44(2S):S70-S74. doi: 10.1097/INF.0000000000004676. Epub 2025 Feb 14.
引用本文的文献
1
Adults in Ghana generate higher and more durable neutralising antibody titres following primary course COVID-19 vaccination than matched UK adults: The HERITAGE Study.加纳成年人在完成新冠疫苗基础免疫后产生的中和抗体滴度高于且比英国匹配的成年人更持久：HERITAGE研究。
BMC Med. 2025 May 28;23(1):312. doi: 10.1186/s12916-025-04157-0.
2
Human cytomegalovirus seropositivity and its influence on oral rotavirus vaccine immunogenicity: a specific concern for HIV-exposed-uninfected infants.人巨细胞病毒血清阳性及其对口服轮状病毒疫苗免疫原性的影响：HIV 暴露但未感染婴儿的特殊关注点。
Clin Exp Immunol. 2024 Jun 20;217(1):99-108. doi: 10.1093/cei/uxae029.
3
Precision Vaccine Development: Cues From Natural Immunity.精准疫苗研发：从天然免疫中获得启示。
Front Immunol. 2022 Feb 10;12:662218. doi: 10.3389/fimmu.2021.662218. eCollection 2021.
4
Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants.与印度尼西亚婴儿对首剂 Edmonston-Zagreb（EZ）麻疹疫苗免疫反应相关的决定因素。
Med Arch. 2021 Oct;75(5):335-339. doi: 10.5455/medarh.2021.75.335-339.
5
Seasonal modulation of antibody response to diphtheria-tetanus-pertussis vaccination in infants: a cohort study in rural Gambia.婴儿对白喉-破伤风-百日咳疫苗的抗体反应的季节性调节：冈比亚农村的一项队列研究。
BMC Public Health. 2021 Jul 22;21(1):1442. doi: 10.1186/s12889-021-11383-7.
6
Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference.迈向精准疫苗：第二届国际精准疫苗大会的经验教训。
Front Immunol. 2020 Oct 15;11:590373. doi: 10.3389/fimmu.2020.590373. eCollection 2020.
7
The CTA1-DD adjuvant strongly potentiates follicular dendritic cell function and germinal center formation, which results in improved neonatal immunization.CTA1-DD 佐剂可显著增强滤泡树突状细胞的功能和生发中心的形成，从而提高新生儿的免疫效果。
Mucosal Immunol. 2020 May;13(3):545-557. doi: 10.1038/s41385-020-0253-2. Epub 2020 Jan 20.
8
Staphylococcus epidermidis Contributes to Healthy Maturation of the Nasal Microbiome by Stimulating Antimicrobial Peptide Production.表皮葡萄球菌通过刺激抗菌肽的产生促进鼻腔微生物组的健康成熟。
Cell Host Microbe. 2020 Jan 8;27(1):68-78.e5. doi: 10.1016/j.chom.2019.11.003. Epub 2019 Dec 19.
9
Impact of nutritional supplementation during pregnancy on antibody responses to diphtheria-tetanus-pertussis vaccination in infants: A randomised trial in The Gambia.孕期营养补充对婴儿对白喉破伤风百日咳疫苗抗体反应的影响：冈比亚的一项随机试验。
PLoS Med. 2019 Aug 6;16(8):e1002854. doi: 10.1371/journal.pmed.1002854. eCollection 2019 Aug.
10
Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA.疫苗接种和感染与不相关的抗体滴度有关：来自德国出生队列研究LISA的分析。
Front Pediatr. 2019 Jun 25;7:254. doi: 10.3389/fped.2019.00254. eCollection 2019.
本文引用的文献
1
Searching for the human genetic factors standing in the way of universally effective vaccines.寻找阻碍通用有效疫苗研发的人类遗传因素。
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0341.
2
Maternal and neonatal tetanus elimination: from protecting women and newborns to protecting all.消除孕产妇和新生儿破伤风：从保护妇女和新生儿到保护所有人。
Int J Womens Health. 2015 Feb 3;7:171-80. doi: 10.2147/IJWH.S50539. eCollection 2015.
3
BCG-associated heterologous immunity, a historical perspective: intervention studies in animal models of infectious diseases.卡介苗相关的异源免疫：历史视角——传染病动物模型中的干预研究
Trans R Soc Trop Med Hyg. 2015 Jan;109(1):52-61. doi: 10.1093/trstmh/tru197.
4
The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination.HIV暴露和母亲结核分枝杆菌感染对婴儿卡介苗接种免疫反应的影响。
AIDS. 2015 Jan 14;29(2):155-65. doi: 10.1097/QAD.0000000000000536.
5
BCG-induced protection: effects on innate immune memory.卡介苗诱导的保护作用：对固有免疫记忆的影响
Semin Immunol. 2014 Dec;26(6):512-7. doi: 10.1016/j.smim.2014.09.006. Epub 2014 Oct 23.
6
A case-control study to estimate the effectiveness of maternal pertussis vaccination in protecting newborn infants in England and Wales, 2012-2013.一项病例对照研究估计 2012-2013 年在英格兰和威尔士，母亲百白破疫苗接种对保护新生儿的效果。
Clin Infect Dis. 2015 Feb 1;60(3):333-7. doi: 10.1093/cid/ciu821. Epub 2014 Oct 19.
7
Why is initial bacterial colonization of the intestine important to infants' and children's health?为什么肠道的初始细菌定植对婴幼儿健康很重要？
J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):294-307. doi: 10.1097/MPG.0000000000000597.
8
Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.四大洲儿童对模式识别受体刺激的先天性细胞因子反应的单细胞分析。
J Immunol. 2014 Sep 15;193(6):3003-3012. doi: 10.4049/jimmunol.1400895. Epub 2014 Aug 18.
9
Effectiveness of maternal pertussis vaccination in England: an observational study.英国母亲百日咳疫苗接种的有效性：一项观察性研究。
Lancet. 2014 Oct 25;384(9953):1521-8. doi: 10.1016/S0140-6736(14)60686-3. Epub 2014 Jul 15.
10
Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial.孕妇接种破伤风白喉无细胞百日咳（Tdap）疫苗的安全性和免疫原性：一项随机临床试验。
JAMA. 2014 May 7;311(17):1760-9. doi: 10.1001/jama.2014.3633.
Zotero 插件