Kampmann Beate, Jones Christine E
Vaccines and Immunity Theme, MRC Unit, The Gambia, Atlantic Road, Fajara, The Gambia Academic Department of Paediatrics, Imperial College London, Norfolk Place, London, UK
Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St George's, University of London, Cranmer Terrace, London, UK.
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). doi: 10.1098/rstb.2014.0148.
Despite significant progress in reducing the burden of mortality in children under the age of five, reducing mortality in newborns remains a major challenge. Infection plays a significant role in infant deaths and interventions such as early vaccination or antenatal immunization could make a significant contribution to prevention of such deaths. In the last few years, we have gained new insights into immune ontogeny and are now beginning to understand the impact of vaccines, nutrition and environmental factors on 'training' of the immune response in early life. This review article sets out to explain why vaccine responses can be heterogeneous between populations and individuals by providing examples chosen to illustrate the impact of host, pathogen and environmental factors on shaping the immune 'interactome' in young children.
尽管在降低五岁以下儿童的死亡负担方面取得了重大进展，但降低新生儿死亡率仍然是一项重大挑战。感染在婴儿死亡中起着重要作用，早期疫苗接种或产前免疫等干预措施对预防此类死亡可做出重大贡献。在过去几年中，我们对免疫个体发生有了新的认识，现在开始了解疫苗、营养和环境因素对生命早期免疫反应“训练”的影响。这篇综述文章旨在通过提供一些例子来解释为什么不同人群和个体之间的疫苗反应可能存在差异，这些例子旨在说明宿主、病原体和环境因素对塑造幼儿免疫“相互作用组”的影响。
