肿瘤表达的白细胞介素-17D 招募 NK 细胞以排斥肿瘤。
Tumor-expressed IL-17D recruits NK cells to reject tumors.
机构信息
Department of Pathology; University of California ; San Diego, CA USA.
Immunology Program; Memorial Sloan-Kettering Cancer Center ; New York, NY USA.
出版信息
Oncoimmunology. 2015 Jan 7;3(12):e954853. doi: 10.4161/21624011.2014.954853. eCollection 2014 Dec.
Abstract
Antitumor immunity suppresses tumorigenesis, but we do not understand how transformed cells initiate those immune responses that are essential for effective tumor immunosurveillance. Using the 3-MCA fibrosarcoma model, we identified IL-17D as a tumor-expressed cytokine that recruits natural killer cells, leading to the polarization of M1 macrophages and tumor rejection.
摘要
抗肿瘤免疫抑制肿瘤发生，但我们并不清楚转化细胞如何引发那些对于有效的肿瘤免疫监视至关重要的免疫反应。利用 3-MCA 纤维肉瘤模型，我们发现了肿瘤表达的细胞因子 IL-17D，它可以招募自然杀伤细胞，导致 M1 巨噬细胞的极化和肿瘤排斥。
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