肿瘤免疫和免疫治疗中的 T(H)17 细胞。
T(H)17 cells in tumour immunity and immunotherapy.
机构信息
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, 48109-0669, USA.
出版信息
Nat Rev Immunol. 2010 Apr;10(4):248-56. doi: 10.1038/nri2742.
Abstract
T helper 17 (T(H)17) cells have well-described roles in autoimmune disease. Recent evidence suggests that this effector T cell subset is also involved in tumour immunology and may be a target for cancer therapy. In this Review, we summarize recent findings regarding the nature and relevance of T(H)17 cells in mouse models of cancer and human disease. We describe the interplay between T(H)17 cells and other immune cells in the tumour microenvironment, and we assess both the potential antitumorigenic and pro-tumorigenic activities of T(H)17 cells and their associated cytokines. Understanding the nature of T(H)17 cell responses in the tumour microenvironment will be important for the design of more efficacious cancer immunotherapies.
摘要
辅助性 T 细胞 17（T(H)17）细胞在自身免疫性疾病中具有明确的作用。最近的证据表明，这个效应 T 细胞亚群也参与肿瘤免疫学，可能成为癌症治疗的靶点。在这篇综述中，我们总结了最近关于 T(H)17 细胞在癌症小鼠模型和人类疾病中的性质和相关性的发现。我们描述了 T(H)17 细胞与肿瘤微环境中其他免疫细胞之间的相互作用，并评估了 T(H)17 细胞及其相关细胞因子的潜在抗肿瘤和促肿瘤活性。了解肿瘤微环境中 T(H)17 细胞反应的性质对于设计更有效的癌症免疫疗法非常重要。
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