Kumar Shiv Basant, Yadav Rashmi, Yadav Raj Kumar, Tolahunase Madhuri, Dada Rima
1Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
2Integral Health Clinic, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
J Altern Complement Med. 2015 Jun;21(6):370-2. doi: 10.1089/acm.2014.0298. Epub 2015 May 12.
Recent studies showed that a brief yoga-based lifestyle intervention was efficacious in reducing levels of oxidative stress and cellular aging in obese men. The objective of this case report was to assess the efficacy of this intervention in reducing the levels of biochemical markers of cellular ageing, oxidative stress, and inflammation at baseline (day 0), at the end of active intervention (day 10), and follow-up at day 90.
Single case report from a prospective ongoing study with pre-post design assessing the level of various markers of cellular aging.
Integral Health Clinic, an outpatient facility conducting meditation and yoga-based lifestyle intervention programs for management of chronic diseases.
A 31-year-old man with class I obesity (body-mass index, 29.5 kg/m(2)) who presented to the medicine outpatient department at All India Institute of Medical Sciences, New Delhi, India, with a history of fatigue, difficulty losing weight, and lack of motivation. He noted a marked decrease in his energy level, particularly in the afternoon.
A pretested intervention program included asanas (postures), pranayama (breathing exercises), stress management, group discussions, lectures, and individualized advice.
From baseline (day 0) to day 90, the activity of telomerase and levels of β-endorphins, plasma cortisol, and interleukin-6 increased, and a sustained reduction in oxidative stress markers, such as reactive oxygen species and 8-hydroxy-2-deoxy-guanosine levels.
Adopting yoga/meditation-based lifestyle modification causes reversal of markers of aging, mainly oxidative stress, telomerase activity, and oxidative DNA damage. This may not only delay aging and prolong a youthful healthy life but also delay or prevent onset of several lifestyle-related diseases, of which oxidative stress and inflammation are the chief cause. This report suggests this simple lifestyle intervention may be therapeutic for oxidative DNA damage and oxidative stress.
近期研究表明，基于瑜伽的简短生活方式干预对降低肥胖男性的氧化应激水平和细胞衰老有效。本病例报告的目的是评估该干预措施在基线期（第0天）、积极干预结束时（第10天）和第90天随访时降低细胞衰老、氧化应激和炎症生化标志物水平的效果。
一项正在进行的前瞻性研究中的单病例报告，采用前后设计评估细胞衰老的各种标志物水平。
综合健康诊所，一家提供基于冥想和瑜伽的生活方式干预项目以管理慢性病的门诊机构。
一名31岁的I级肥胖男性（体重指数，29.5 kg/m²），因疲劳、减肥困难和缺乏动力前往印度新德里全印度医学科学研究所内科门诊就诊。他注意到自己的精力水平明显下降，尤其是在下午。
一个经过预测试的干预项目包括体式（姿势）、呼吸法（呼吸练习）、压力管理、小组讨论、讲座和个性化建议。
从基线期（第0天）到第90天，端粒酶活性以及β-内啡肽、血浆皮质醇和白细胞介素-6水平升高，同时氧化应激标志物如活性氧和8-羟基-2-脱氧鸟苷水平持续降低。
采用基于瑜伽/冥想的生活方式改变可使衰老标志物发生逆转，主要是氧化应激、端粒酶活性和氧化性DNA损伤。这不仅可能延缓衰老、延长年轻健康的寿命，还可能延缓或预防几种与生活方式相关疾病的发生，其中氧化应激和炎症是主要原因。本报告表明这种简单的生活方式干预可能对氧化性DNA损伤和氧化应激具有治疗作用。
