Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
J Altern Complement Med. 2013 May;19(5):397-402. doi: 10.1089/acm.2012.0086. Epub 2012 Dec 4.
To investigate the effect of a short-term yoga-based lifestyle intervention on risk factors for cardiovascular disease (CVD) and markers of inflammation and endothelial function in overweight and obese men.
Nonrandomized prospective lifestyle intervention study with pre-post design. SETTING AND LOCATION: Integral Health Clinic, an outpatient facility providing yoga-based lifestyle intervention programs for prevention and management of chronic diseases.
Overweight and obese men (n=51) were enrolled in the study. Subjects who were physically unable to participate and those participating in other interventions were excluded from the study.
A pretested intervention program including asanas (physical postures), pranayama (breathing exercises), group discussions, lectures, and individualized advice.
The primary outcome measure was weight loss, and the secondary outcome measures were clinical and laboratory correlates of CVD risk, levels of interleukin-6 (IL-6), adiponectin, and endothelin-1 (ET-1).
Men (n=51, body mass index [BMI] 26.26±2.42 kg/m(2)) were enrolled and underwent a yoga-based lifestyle intervention for 10 days. Of 51 subjects, 30 completed the study. There was a significant reduction in weight from Baseline to Day 10 (74.60±7.98, 72.69±8.37 kg, p<0.001, respectively), BMI (26.26±2.42, 25.69±2.47 kg/m(2), p<0.001, respectively), and systolic BP (121.73±11.58, 116.73±9.00, p=0.042, respectively). There was a significant reduction in plasma IL-6 from Baseline to Day 10 (median 2.24 vs. 1.26 pg/mL, respectively, p=0.012). There was a significant increase in the plasma adiponectin from Baseline to Day 10 (median 4.95 vs. 6.26 μg/mL, respectively, p=0.014). Plasma ET-1 level remained unchanged.
These findings suggest that even a short-term yoga-based lifestyle intervention may be an important modality to reduce the risk for CVD as indicated by weight loss, reduction in systolic blood pressure, an increase in adiponectin, and decrease in IL-6 in overweight and obese men.
探讨短期瑜伽生活方式干预对超重和肥胖男性心血管疾病（CVD）风险因素及炎症和内皮功能标志物的影响。
非随机前瞻性生活方式干预研究，设计前-后对照。
Integral Health Clinic，一家为预防和管理慢性疾病提供基于瑜伽的生活方式干预计划的门诊诊所。
超重和肥胖男性（n=51）参加了本研究。身体无法参与的受试者和参与其他干预措施的受试者被排除在研究之外。
经过预测试的干预方案，包括体式（身体姿势）、呼吸练习（pranayama）、小组讨论、讲座和个性化建议。
体重减轻是主要结局指标，次要结局指标是心血管疾病风险的临床和实验室相关指标、白细胞介素-6（IL-6）、脂联素和内皮素-1（ET-1）的水平。
51 名男性（BMI 26.26±2.42 kg/m2）参加了基于瑜伽的生活方式干预研究，共 10 天。51 名受试者中有 30 名完成了研究。体重从基线到第 10 天显著下降（分别为 74.60±7.98、72.69±8.37kg，p<0.001），BMI（分别为 26.26±2.42、25.69±2.47kg/m2，p<0.001）和收缩压（分别为 121.73±11.58、116.73±9.00，p=0.042）。血浆 IL-6 从基线到第 10 天显著下降（中位数分别为 2.24 和 1.26pg/mL，p=0.012）。血浆脂联素从基线到第 10 天显著升高（中位数分别为 4.95 和 6.26μg/mL，p=0.014）。血浆 ET-1 水平保持不变。
这些发现表明，即使是短期基于瑜伽的生活方式干预，也可能是一种重要的方式，可以通过减轻体重、降低收缩压、增加脂联素和降低超重和肥胖男性的白细胞介素-6 来降低 CVD 的风险。
