Ankri Lea, Husson Zoé, Pietrajtis Katarzyna, Proville Rémi, Léna Clément, Yarom Yosef, Dieudonné Stéphane, Uusisaari Marylka Yoe
Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France.
Elife. 2015 May 12;4:e06262. doi: 10.7554/eLife.06262.
The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.
小脑是运动协调的关键中枢，由皮质和几个神经核组成。这两个部分之间的主要相互作用模式被认为是由皮质浦肯野神经元对神经核的抑制性控制形成的。我们现在修正这一观点，表明小脑神经核（CN）的抑制性γ-氨基丁酸-甘氨酸能神经元大量投射到小脑皮质，在那里它们与小脑高尔基细胞的γ-氨基丁酸能亚群形成突触联系。这些自发放电的高尔基细胞在体外和体内均受到抑制性核-皮质纤维的光遗传学激活的抑制。我们的数据表明，CN可能通过减少高尔基细胞对颗粒细胞的抑制来促进小脑皮质的功能募集。
