Held Manuel, Rothenberger Jens, Tolzmann Dascha, Petersen Wiebke, Schaller Hans-Eberhard, Rahmanian-Schwarz Afshin
BG-Trauma Center, Eberhard Karls University, Tuebingen, Germany; email:
BG-Trauma Center, Eberhard Karls University, Tuebingen, Germany.
Wounds. 2015 May;27(5):123-8.
The incidence of partial-thickness wounds is high and, until recently, little was known about the alteration of the biomechanical properties of the skin in these wounds during the course of healing. The aim of this study was to demonstrate the biomechanical changes in skin elasticity.
Fourteen standardized skin defects were created on the back of fourteen adult male Lewis rats (Charles River Laboratories International, Inc, Wilmington, MA) using a skin dermatome. Biomechanical properties of the skin were determined every 10 days over a period of 3 months using a skin elasticity measurement device (Cutometer MPA 580, Courage and Khazaka, Cologne, Germany). Calculated elasticity (UE), firmness of skin (R0), and overall elasticity (R8) were assessed. In addition, histological evaluation was performed in regard to quality of skin.
After an initial decrease of UE, R0, and R8 until 30 days after surgery, the values of R0 and R8 increased between day 50 and day 60. Starting on day 60, a further decrease of values was indicated.
The alteration of biomechanical properties of skin is a function of tissue structure. The presented results demonstrate the complex changes of skin biomechanical properties in the course of healing of partial-thickness wounds. This study could serve as a model to compare the effectiveness of different wound dressings in regard to skin elasticity.
部分厚度伤口的发生率很高，直到最近，对于这些伤口在愈合过程中皮肤生物力学特性的改变仍知之甚少。本研究的目的是证明皮肤弹性的生物力学变化。
使用皮肤切片机在14只成年雄性Lewis大鼠（查尔斯河实验室国际公司，马萨诸塞州威尔明顿）的背部创建14个标准化的皮肤缺损。在3个月的时间里，每隔10天使用皮肤弹性测量装置（Cutometer MPA 580，德国科隆的Courage and Khazaka公司）测定皮肤的生物力学特性。评估计算得出的弹性（UE）、皮肤硬度（R0）和整体弹性（R8）。此外，对皮肤质量进行了组织学评估。
术后30天内UE、R0和R8最初下降，R0和R8的值在第50天至第60天之间增加。从第60天开始，数值进一步下降。
皮肤生物力学特性的改变是组织结构的一种功能。所呈现的结果证明了部分厚度伤口愈合过程中皮肤生物力学特性的复杂变化。本研究可作为一个模型，用于比较不同伤口敷料在皮肤弹性方面的有效性。
