番石榴素A以及番石榴素B和C：从番石榴叶中分离得到的三种具有独特骨架的新型半萜类化合物。

Guapsidial A and Guadials B and C: Three New Meroterpenoids with Unusual Skeletons from the Leaves of Psidium guajava.

作者信息

Jian Yu-Qing, Huang Xiao-Jun, Zhang Dong-Mei, Jiang Ren-Wang, Chen Min-Feng, Zhao Bing-Xin, Wang Ying, Ye Wen-Cai

机构信息

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632 (P.R. China), Fax: (+86) 20-8522-1559.

JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University, Guangzhou 510632 (P.R. China).

出版信息

Chemistry. 2015 Jun 15;21(25):9022-7. doi: 10.1002/chem.201500533. Epub 2015 May 12.

DOI:10.1002/chem.201500533

PMID:25965842

Abstract

A novel sesquiterpene-based Psidium meroterpenoid, possessing an unusual coupling pattern, and two new monoterpene-based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava. Their structures and absolute configurations were elucidated by spectroscopic, X-ray diffraction, and computational methods. The plausible biosynthetic pathway of these meroterpenoids as well as their cytotoxicities toward HepG2 and HepG2/ADM cells were also discussed.

摘要

从番石榴叶中分离出一种具有新颖倍半萜基的半萜类化合物，其具有不寻常的偶合模式，以及两种具有前所未有的骨架的新型单萜基半萜类化合物。通过光谱、X射线衍射和计算方法阐明了它们的结构和绝对构型。还讨论了这些半萜类化合物可能的生物合成途径以及它们对HepG2和HepG2/ADM细胞的细胞毒性。