Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
Org Lett. 2010 Nov 5;12(21):5040-3. doi: 10.1021/ol102179u.
Psiguadials A (1) and B (2), two novel sesquiterpenoid-diphenylmethane meroterpenoids with unusual skeletons, along with a pair of known epimers, psidial A (3) and guajadial (4), were isolated from the leaves of Psidium guajava. Their structures with absolute configurations were elucidated by means of NMR, X-ray diffraction, and quantum chemical CD calculation. Compounds 1, 2, and 4 exhibited potent inhibitory effects on the growth of human hepatoma cells.
Psiguadials A (1) 和 B (2)，两种新型倍半萜-二苯甲烷杂合二萜，具有不寻常的骨架，以及一对已知的差向异构体，psidial A (3) 和 guajadial (4)，从番石榴叶中分离得到。通过 NMR、X 射线衍射和量子化学 CD 计算确定了它们的结构和绝对构型。化合物 1、2 和 4 对人肝癌细胞的生长表现出强烈的抑制作用。
