Eshraghi Tahereh, Eidi Akram, Mortazavi Pejman, Asghari Ahmad, Tavangar Seyyed Mohammad
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Magnes Res. 2015 Jan-Mar;28(1):32-45. doi: 10.1684/mrh.2015.0380.
The aim of this study was to investigate the effects of magnesium sulfate (MgSO4) on cholestasis-induced hepatic injury after bile duct ligation (BDL) in male Wistar rats. In this study, the effects of 28-day, oral administration of MgSO4 (at doses of 0.01, 0.05, 0.1, and 0.2 g/kg bw) were evaluated in normal and BDL-induced cholestatic rats. The BDL group showed significant increases in serum levels of ALP, ALT, AST, GGT and significant decreases in hepatic SOD and catalase activities. BDL rats also had significant decreases in the serum levels of albumin, bilirubin, total cholesterol, triglycerides, and LDL. Administration of MgSO4 significantly attenuated these changes to nearly normal levels. Administrations of MgSO4 did not change these parameters in normal rats. Histopathological studies further confirmed the protective effects of MgSO4 on cholestasis-induced hepatic injury in the BDL rat model. Taken together, the results of this study suggest that MgSO4 treatment may be beneficial in cholestasis-induced hepatotoxicity.
本研究旨在探讨硫酸镁（MgSO4）对雄性Wistar大鼠胆管结扎（BDL）后胆汁淤积性肝损伤的影响。在本研究中，对正常大鼠和BDL诱导的胆汁淤积大鼠评估了连续28天口服MgSO4（剂量为0.01、0.05、0.1和0.2 g/kg体重）的效果。BDL组血清碱性磷酸酶（ALP）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰转肽酶（GGT）水平显著升高，肝超氧化物歧化酶（SOD）和过氧化氢酶活性显著降低。BDL大鼠血清白蛋白、胆红素、总胆固醇、甘油三酯和低密度脂蛋白（LDL）水平也显著降低。给予MgSO4可使这些变化显著减轻至接近正常水平。给予MgSO4对正常大鼠这些参数无影响。组织病理学研究进一步证实了MgSO4对BDL大鼠模型中胆汁淤积性肝损伤的保护作用。综上所述，本研究结果表明MgSO4治疗可能对胆汁淤积性肝毒性有益。
