Torres-Durán María, Ruano-Ravina Alberto, Parente-Lamelas Isaura, Leiro-Fernández Virginia, Abal-Arca José, Montero-Martínez Carmen, Pena-Álvarez Carolina, Castro-Añón Olalla, Golpe-Gómez Antonio, Martínez Cristina, Guzmán-Taveras Rosirys, Mejuto-Martí María José, Provencio Mariano, Fernández-Villar Alberto, Barros-Dios Juan Miguel
a Service of Neumology, University Hospital Complex of Vigo , Spain.
b Department of Preventive Medicine and Public Health , University of Santiago de Compostela , Spain.
Int J Radiat Biol. 2015 Aug;91(8):605-10. doi: 10.3109/09553002.2015.1047985. Epub 2015 Jun 17.
The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis.
We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included 216 never-smoking cases with primary lung cancer and 329 never-smoking controls. Controls were frequency matched with cases on age and sex distribution. Of them, 198 cases (91.7%) and 275 controls (83.5%) had residential radon measurements.
Lung cancer risk reached statistical significance only for adenocarcinoma (Odds ratio [OR] 2.19; 95% Confidence interval [CI] 1.44-3.33), for other histologies the results were marginally significant. Residential radon level was higher for patients diagnosed before 50 and 60 years old than for older lung cancer cases.
Residential radon in never smokers seems to be a risk factor for all lung cancer histologies. Individuals diagnosed at a younger age have a higher residential radon concentration, suggesting an accumulative effect on lung cancer appearance.
本研究旨在评估居住环境中的氡与肺癌组织学类型以及患者确诊时年龄之间是否存在关联。
我们开展了一项基于医院的多中心病例对照研究，有八家参与医院。我们纳入了216例原发性肺癌的从不吸烟者病例以及329例从不吸烟者对照。对照在年龄和性别分布上与病例进行频率匹配。其中，198例病例（91.7%）和275例对照（83.5%）进行了居住环境氡测量。
仅腺癌的肺癌风险达到统计学显著性（比值比[OR] 2.19；95%置信区间[CI] 1.44 - 3.33），其他组织学类型的结果为边缘显著。50岁及60岁之前确诊的患者居住环境氡水平高于年龄较大的肺癌病例。
从不吸烟者居住环境中的氡似乎是所有肺癌组织学类型的一个风险因素。确诊时年龄较小的个体居住环境氡浓度较高，提示对肺癌发生有累积效应。
