Department of Preventive Medicine and Public Health, Facultade de Medicina, University of Santiago de Compostela, Rua San Francisco S/N, 15782, Santiago de Compostela, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública/CIBERESP), Madrid, Spain.
Clin Transl Oncol. 2023 Dec;25(12):3357-3368. doi: 10.1007/s12094-023-03308-0. Epub 2023 Aug 23.
We aim to provide an overview of the research available on indoor radon and lung cancer, with a special focus on Spanish investigations. Early studies on underground miners established the link between radon and lung cancer, which was later confirmed for the general population by residential case-control studies. Spain contributed with extensive evidence, including 5 multicentric, hospital-based, case-control studies in the last 30 years, exploring diverse aspects, such as radon's effect on never-smokers, molecular pathways linking radon exposure to lung cancer risk, survival rates, mortality burden, and occupational exposure. There is a well-established causal association between radon with lung cancer. Despite pioneering research performed in our country by the Galician Radon Laboratory, particularly on driver genes, the evidence on the potential molecular pathways which makes radon a carcinogen is sparse. Also, relevant questions on the potential association of radon exposure with the induction of other diseases are still pending.
我们旨在提供关于室内氡气与肺癌的研究综述，特别关注西班牙的调查研究。早期对地下矿工的研究确立了氡气与肺癌之间的联系，后来通过住宅病例对照研究也证实了氡气对一般人群的影响。西班牙提供了广泛的证据，包括过去 30 年的 5 项多中心、基于医院的病例对照研究，探索了氡气对从不吸烟者的影响、将氡气暴露与肺癌风险联系起来的分子途径、生存率、死亡率负担以及职业暴露等不同方面。氡气与肺癌之间存在着明确的因果关系。尽管西班牙加利西亚氡气实验室在这方面进行了开创性的研究，特别是在驱动基因方面，但关于使氡气成为致癌物的潜在分子途径的证据仍然很少。此外，氡气暴露与其他疾病的潜在关联的相关问题仍有待解决。
