Guo Xiaoqiang, Deng Li, Deng Kaiyuan, Wang Hao, Shan Ting, Zhou Hong, Liang Zheng, Xia Jiazeng, Li Chenglong
Department of Vascular Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Anticancer Agents Med Chem. 2016;16(4):456-64. doi: 10.2174/1871520615666150507121407.
PTENP1 has been demonstrated to function as a tumor suppressor in several cancer cells. However, its expression and biological roles in gastric cancer (GC) have not yet been investigated. In this study, we demonstrated that PTENP1 was frequently decreased in GC tissues and cell lines, which might be partly associated with DNA hypermethylation, and lower PTENP1 expression was associated with larger tumor size, more advanced stage, deeper invasion depth and lymphatic metastasis. In addition, our data suggested that PTENP1 could regulate GC cell proliferation, apoptosis, migration and invasion in vitro. Furthermore, we demonstrated that PTENP1 could modulate the PTEN protein expression. Taken together, these results suggest that PTENP1 functions as a novel tumor suppressor in GC and its suppressive ability may be involved in the modulation of PTEN.
PTENP1已被证明在多种癌细胞中发挥肿瘤抑制作用。然而，其在胃癌（GC）中的表达及生物学作用尚未得到研究。在本研究中，我们证明PTENP1在GC组织和细胞系中经常下调，这可能部分与DNA高甲基化有关，且PTENP1表达降低与肿瘤体积较大、分期较晚、浸润深度更深及淋巴转移有关。此外，我们的数据表明PTENP1可在体外调节GC细胞的增殖、凋亡、迁移和侵袭。此外，我们证明PTENP1可调节PTEN蛋白表达。综上所述，这些结果表明PTENP1在GC中作为一种新型肿瘤抑制因子发挥作用，其抑制能力可能参与PTEN的调节。
