Birkelund Thomas, Obad Damir Salskov, Matejec Reginald, Bøtker Hans Erik, Ravn Hanne Berg
a Department of Anesthesiology and Intensive Care , Aarhus University Hospital , Skejby , Denmark.
Scand Cardiovasc J. 2015;49(5):257-63. doi: 10.3109/14017431.2015.1046401. Epub 2015 May 20.
The aim of the present study was to compare changes in circulating levels of proopiomelanocortin (POMC) derivates and lactate after remote ischemic preconditioning (IPC) and physical exercise.
Remote IPC (rIPC) is cardioprotective following acute myocardial infarction and major cardiac surgery. A blood-borne, transferable factor, released following not only rIPC but also vigorous exercise, mediates protection that is abolished by naloxone suggesting involvement of an opioid-receptor-dependent pathway.
Eight healthy volunteers underwent rIPC by four cycles of 5-min inflation of a pneumatic tourniquet to 200 mmHg interrupted by 5 min of deflation. Subsequently, circulating plasma levels of POMC derivates, cortisol, and lactate were measured. After 3 days, the volunteers completed a vigorous exercise program, after which the same compounds were measured.
While rIPC was not associated with any significant increase in circulating POMC derivates or lactate, exercise induced significant elevation of both compared with baseline.
We were not able to demonstrate a detectable increase in circulating POMC derivates by a standard rIPC stimulus, suggesting that rIPC effect is not mediated by local or detectable central release of these derivates.
本研究旨在比较远隔缺血预处理（IPC）和体育锻炼后阿片促黑皮质素原（POMC）衍生物及乳酸循环水平的变化。
远隔IPC（rIPC）对急性心肌梗死和心脏大手术后具有心脏保护作用。一种不仅在rIPC后而且在剧烈运动后释放的血源性、可转移因子介导了这种保护作用，纳洛酮可消除这种保护作用，提示其涉及阿片受体依赖性途径。
8名健康志愿者接受rIPC，通过将气动止血带充气至200 mmHg并持续5分钟，放气5分钟，重复4个周期。随后，测量POMC衍生物、皮质醇和乳酸的循环血浆水平。3天后，志愿者完成一项剧烈运动计划，之后测量相同的化合物。
虽然rIPC与循环POMC衍生物或乳酸的任何显著增加均无关联，但与基线相比，运动导致两者均显著升高。
我们未能通过标准的rIPC刺激证明循环POMC衍生物有可检测到的增加，这表明rIPC的作用不是由这些衍生物的局部或可检测到的中枢释放介导的。
