Bhowmik Bishwajit, Afsana Faria, Siddiquee Tasnima, Munir Sanjida B, Sheikh Fareeha, Wright Erica, Bhuiyan Farjana R, Ashrafuzzaman Sheikh Mohammad, Mahtab Hajera, Azad Khan Abul Kalam, Hussain Akhtar
Department of Community Medicine, Institute of Health and Society, University of Oslo Oslo, Norway.
Department of Endocrinology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) Dhaka, Bangladesh.
J Diabetes Investig. 2015 May;6(3):280-8. doi: 10.1111/jdi.12268. Epub 2014 Aug 25.
AIMS/INTRODUCTION: To compare the prevalence of metabolic syndrome (MS) using the modified National Cholesterol Education Program Adult Treatment Plan III (NCEP) and the International Diabetes Federation (IDF) definitions and, using both definitions, determine and compare the association of MS, prediabetes, type 2 diabetes, hypertension (HTN) and cardiovascular disease risk (CVD).
A total of 2,293 randomly selected participants (aged ≥20 years) in a rural community in Bangladesh were investigated in a population-based cross-sectional study. Sociodemographic and anthropometric characteristics, blood pressure, blood glucose, and lipid profiles were studied. Age-adjusted data for MS and cardiometabolic risk factors were assessed, and their relationships were examined.
The age-adjusted prevalence of MS was 30.7% (males 30.5%; females 30.5%) using the NCEP definition, and 24.5% (males 19.2%, females 27.5%) using the IDF definition. The prevalence of MS using the NCEP definition was also higher in study participants with prediabetes, type 2 diabetes, HTN and CVD risk. The agreement rate between both definitions was 92% (k = 0.80). The NCEP definition had a stronger association with type 2 diabetes and HTN (odds ratio 12.4 vs 5.2; odds ratio 7.0 vs 4.7, respectively) than the IDF definition. However, the odds ratios for prediabetes and CVD risk were not significantly different.
The prevalence of MS was higher using the NCEP definition, and was more strongly associated with prediabetes, type 2 diabetes, HTN and CVD in this Bangladeshi population.
目的/引言：使用修改后的美国国家胆固醇教育计划成人治疗计划第三次报告（NCEP）和国际糖尿病联盟（IDF）的定义比较代谢综合征（MS）的患病率，并使用这两种定义确定和比较MS、糖尿病前期、2型糖尿病、高血压（HTN）和心血管疾病风险（CVD）之间的关联。
在一项基于人群的横断面研究中，对孟加拉国一个农村社区随机选取的2293名年龄≥20岁的参与者进行了调查。研究了社会人口统计学和人体测量学特征、血压、血糖和血脂谱。评估了MS和心血管代谢危险因素的年龄调整数据，并检查了它们之间的关系。
使用NCEP定义，MS的年龄调整患病率为30.7%（男性30.5%；女性30.5%），使用IDF定义为24.5%（男性19.2%，女性27.5%）。在患有糖尿病前期、2型糖尿病、HTN和CVD风险的研究参与者中，使用NCEP定义的MS患病率也更高。两种定义之间的一致率为92%（k = 0.80）。与IDF定义相比，NCEP定义与2型糖尿病和HTN的关联更强（优势比分别为12.4对5.2；7.0对4.7）。然而，糖尿病前期和CVD风险的优势比没有显著差异。
在这个孟加拉人群中，使用NCEP定义时MS的患病率更高，并且与糖尿病前期、2型糖尿病、HTN和CVD的关联更强。
