Chackrewarthy S, Gunasekera D, Pathmeswaren A, Wijekoon C N, Ranawaka U K, Kato N, Takeuchi F, Wickremasinghe A R
Faculty of Medicine, University of Kelaniya, 11010 Ragama, Sri Lanka.
ISRN Endocrinol. 2013;2013:320176. doi: 10.1155/2013/320176. Epub 2013 Feb 27.
Background. The prevalence of metabolic syndrome (MetS) within individual cohorts varies with the definition used. The aim of this study was to compare the prevalence of MetS between IDF and revised NCEP ATP III criteria in an urban Sri Lankan population and to investigate the characteristics of discrepant cases. Methods. 2985 individuals, aged 35-65 years, were recruited to the study. Anthropometric and blood pressure measurements and laboratory investigations were carried out following standard protocols. Results. Age and sex-adjusted prevalences of MetS were 46.1% and 38.9% by revised NCEP and IDF definitions, respectively. IDF criteria failed to identify 21% of men and 7% of women identified by the revised NCEP criteria. The discrepant group had more adverse metabolic profiles despite having a lower waist circumference than those diagnosed by both criteria. Conclusion. MetS is common in this urban Sri Lankan cohort regardless of the definition used. The revised NCEP definition was more appropriate in identifying the metabolically abnormal but nonobese individuals, especially among the males predisposed to type 2 diabetes or cardiovascular disease. Further research is needed to determine the suitability of the currently accepted Asian-specific cut-offs for waist circumference in Sri Lankan adults.
背景。代谢综合征（MetS）在各个队列中的患病率因所采用的定义而异。本研究的目的是比较国际糖尿病联盟（IDF）和修订后的美国国家胆固醇教育计划成人治疗组第三次报告（NCEP ATP III）标准在斯里兰卡城市人群中MetS的患病率，并调查不一致病例的特征。方法。招募了2985名年龄在35 - 65岁之间的个体参与研究。按照标准方案进行人体测量、血压测量和实验室检查。结果。根据修订后的NCEP和IDF定义，年龄和性别调整后的MetS患病率分别为46.1%和38.9%。IDF标准未能识别出修订后的NCEP标准所识别的男性中的21%和女性中的7%。尽管不一致组的腰围低于两种标准都诊断出的组，但他们有更不利的代谢特征。结论。无论采用何种定义，MetS在这个斯里兰卡城市队列中都很常见。修订后的NCEP定义在识别代谢异常但非肥胖个体方面更合适，尤其是在易患2型糖尿病或心血管疾病的男性中。需要进一步研究以确定目前公认的亚洲特定腰围切点在斯里兰卡成年人中的适用性。
