Banan Parastoo, Marvi Salman K, McMeniman Erin, De'Ambrosis Brian
Dermatology Research Centre, The University of Queensland, School of Medicine, Translational Research Institute, Brisbane, Queensland, Australia.
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Australas J Dermatol. 2016 Feb;57(1):29-32. doi: 10.1111/ajd.12278. Epub 2015 Feb 25.
Patients with a history of non-melanoma skin cancer (NMSC) have a 50% risk of developing subsequent NMSC.(13) Currently there are limited data on the association between multiple squamous cell carcinomas (SCC) and the risk of other cancers, including melanomas.
To assess the risk factors in a cohort of 210 Australians with a history of multiple invasive SCC, focusing on the association between multiple SCC and other cancers.
Data were collected from patients of a private practice in south-east Queensland.
A fair complexion and childhood sun exposure were found to be common in this cohort. Approximately half the patients who had their first SCC at or before the age of 30 years subsequently developed a melanoma. There was also an increased risk of internal cancer, prostate cancer being the commonest, followed by bowel and breast cancer.
Patients with a history of multiple invasive SCC should be aware of their increased risk of future NMSC and of melanomas. The results of thisstudy suggest such patients and their care providers should also consider an appropriate screening for internal malignancies.
有非黑色素瘤皮肤癌（NMSC）病史的患者发生后续NMSC的风险为50%。（13）目前，关于多发性鳞状细胞癌（SCC）与包括黑色素瘤在内的其他癌症风险之间关联的数据有限。
评估210名有多发侵袭性SCC病史的澳大利亚人的危险因素，重点关注多发性SCC与其他癌症之间的关联。
数据收集自昆士兰州东南部一家私人诊所的患者。
在该队列中发现肤色白皙和儿童期阳光暴露很常见。约一半在30岁及以前首次发生SCC的患者随后发生了黑色素瘤。内部癌症风险也增加，前列腺癌最为常见，其次是肠癌和乳腺癌。
有多发侵袭性SCC病史的患者应意识到其未来发生NMSC和黑色素瘤的风险增加。本研究结果表明，此类患者及其护理人员还应考虑对内部恶性肿瘤进行适当筛查。
