Department of Surgery, Royal North Shore Hospital, New South Wales, Australia.
Cancer Research Division, Cancer Council NSW, Sydney, NSW, Australia.
Sci Rep. 2018 May 8;8(1):7167. doi: 10.1038/s41598-018-25408-6.
Emerging evidence suggests that a diagnosis of cutaneous melanoma (CM) may be associated with prostate cancer (PC) incidence. We examined if the incidence of CM was associated with an increased subsequent risk of PC. We used data from the New South Wales Cancer Registry for all CM and PC cases diagnosed between January 1972 and December 2008. We calculated the age standardized incidence ratio (SIR) and 95% confidence intervals (95% CI) for PC incidence following a CM diagnosis, applying age- and calendar- specific rates to the appropriate person years at risk. We determined rate ratio (RR) and 95% CI of PC incidence according to specified socio-demographic categories and disease related characteristics, using a negative binomial model. There were 143,594 men diagnosed with PC or CM in the study period and of these 101,198 and 42,396 were diagnosed with PC and CM, respectively, as first primary cancers. Risk of PC incidence increased following CM diagnosis (n = 2,114; SIR = 1.25; 95% CI:1.20.8-1.31: p < 0.0001), with the increased risk apparent in men diagnosed with localised CM (n = 1,862;SIR = 1.26; 95% CI:1.20-1.32). CM diagnosis increased the subsequent risk of PC incidence. This raises the potential for future PC risk to be discussed with newly diagnosed males with CM.
新出现的证据表明，皮肤黑色素瘤（CM）的诊断可能与前列腺癌（PC）的发病有关。我们研究了 CM 的发病率是否与随后 PC 发病风险的增加有关。我们使用了 1972 年 1 月至 2008 年 12 月期间新南威尔士癌症登记处的数据，来诊断所有的 CM 和 PC 病例。我们计算了 CM 诊断后 PC 发病率的年龄标准化发病率比（SIR）和 95%置信区间（95%CI），将年龄和日历特定的发病率应用于适当的人年风险。我们根据特定的社会人口统计学类别和疾病相关特征，使用负二项式模型确定了 PC 发病率的比率比（RR）和 95%CI。在研究期间，有 143594 名男性被诊断患有 PC 或 CM，其中 101198 名和 42396 名分别被诊断为 PC 和 CM 作为首发原发性癌症。CM 诊断后 PC 发病风险增加（n=2114；SIR=1.25；95%CI：1.20-1.31：p<0.0001），局部 CM 诊断的男性风险增加（n=1862；SIR=1.26；95%CI：1.20-1.32）。CM 诊断增加了随后 PC 发病的风险。这提示，在诊断为 CM 的新发男性中，未来 PC 风险的讨论可能会增加。
