Zhou Yan-Heng, Chen Xin, Liang Yue-Bo, Pang Wei, Qin Wei-Hong, Zhang Chiyu, Zheng Yong-Tang
1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology , Chinese Academy of Sciences, Kunming, Yunnan, China .
2 Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan'an University , Yan'an, Shaanxi, China .
AIDS Res Hum Retroviruses. 2015 Aug;31(8):845-50. doi: 10.1089/AID.2015.0021. Epub 2015 Jun 15.
The Myanmar-China border appears to be the "hot spot" region for the occurrence of HIV-1 recombination. The majority of the previous analyses of HIV-1 recombination were based on partial genomic sequences, which obviously cannot reflect the reality of the genetic diversity of HIV-1 in this area well. Here, we present a near full-length characterization of a novel HIV-1 CRF01_AE/B/C recombinant isolated from a long-distance truck driver in Northern Myanmar. It is the first description of a near full-length genomic sequence in Myanmar since 2003, and might be one of the most complicated HIV-1 chimeras ever detected in Myanmar, containing four CRF01_AE, six B segments, and five C segments separated by 14 breakpoints throughout its genome. The discovery and characterization of this new CRF01_AE/B/C recombinant indicate that intersubtype recombination is ongoing in Myanmar, continuously generating new forms of HIV-1. More work based on near full-length sequence analyses is urgently needed to better understand the genetic diversity of HIV-1 in these regions.
中缅边境似乎是HIV-1重组发生的“热点”地区。此前大多数对HIV-1重组的分析都是基于部分基因组序列，显然这无法很好地反映该地区HIV-1基因多样性的实际情况。在此，我们展示了从缅甸北部一名长途卡车司机身上分离出的一种新型HIV-1 CRF01_AE/B/C重组体的近乎全长的特征。这是自2003年以来缅甸首次对近乎全长基因组序列的描述，可能是在缅甸检测到的最复杂的HIV-1嵌合体之一，其基因组中包含四个CRF01_AE、六个B片段和五个C片段，由14个断点隔开。这种新的CRF01_AE/B/C重组体的发现和特征表明，缅甸正在发生亚型间重组，不断产生新形式的HIV-1。迫切需要开展更多基于近乎全长序列分析的工作，以更好地了解这些地区HIV-1的基因多样性。
