炎症状态下人牙龈组织中半胱氨酸蛋白酶抑制剂胱抑素C的免疫化学定量分析

Immunochemical quantitation of cysteine proteinase inhibitor cystatin C in inflamed human gingiva.

作者信息

Skaleric U, Babnik J, Curin V, Lah T, Turk V

机构信息

Department of Oral Medicine and Periodontology, University Dental Clinic, Ljubljana, Yugoslavia.

出版信息

Arch Oral Biol. 1989;34(4):301-5. doi: 10.1016/0003-9969(89)90072-1.

DOI:10.1016/0003-9969(89)90072-1

PMID:2597024

Abstract

The amount of the low molecular-weight inhibitor, cystatin C, was determined by the enzyme-linked immunosorbent assay. Gingival tissue samples were obtained during periodontal surgery from 22 patients with different degrees of inflammatory periodontal disease, as indicated by gingival index and probing depth (PD). The concentration of cystatin C was in the range from 0.21 to 3.82 micrograms/g tissue and was significantly decreased (p less than 0.01) in samples taken from sites with increased PD.

摘要

采用酶联免疫吸附测定法测定低分子量抑制剂胱抑素C的含量。在牙周手术期间，从22例患有不同程度炎症性牙周病的患者身上获取牙龈组织样本，这些患者的炎症程度通过牙龈指数和探诊深度（PD）来表示。胱抑素C的浓度在0.21至3.82微克/克组织范围内，并且在从PD增加部位采集的样本中显著降低（p小于0.01）。