van Gils P C, Brand H S, Timmerman M F, Veerman E C I, van der Velden U, van der Weijden G A
Department of Periodontology, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands.
J Clin Periodontol. 2003 Oct;30(10):882-6. doi: 10.1034/j.1600-051x.2003.00394.x.
Subjects with natural gingivitis and periodontitis have elevated levels of salivary cystatins compared to periodontally healthy individuals. Experimental gingivitis studies, however, have yielded conflicting results.
The present study investigated whether experimentally induced gingivitis is associated with changes in salivary cystatin levels.
MATERIAL & METHODS: Plaque scores, bleeding indexes and whole saliva samples of 35 non-smoking young adults were collected at the start and at the end of an experimental gingivitis trial, and 3 weeks after resuming oral hygiene. The saliva samples were assayed for protein concentrations, cystatin activity and cystatin C concentration.
During experimental gingivitis, plaque and bleeding scores increased significantly in all subjects and subsequently decreased significantly after reinstalment of oral hygiene procedures. No significant changes were observed for the protein concentration, cystatin activity and cystatin C concentration. No significant relation could be established between these salivary parameters and bleeding on marginal probing.
The present study confirms earlier results from Lie et al. (2001) that no significant changes occur in salivary cystatin activity and cystatin C concentration during and after experimental gingivitis.
与牙周健康个体相比，患有自然牙龈炎和牙周炎的受试者唾液胱抑素水平升高。然而，实验性牙龈炎研究得出了相互矛盾的结果。
本研究调查实验性诱导的牙龈炎是否与唾液胱抑素水平的变化有关。
在一项实验性牙龈炎试验开始时、结束时以及恢复口腔卫生3周后，收集了35名不吸烟的年轻成年人的菌斑评分、出血指数和全唾液样本。对唾液样本进行蛋白质浓度、胱抑素活性和胱抑素C浓度检测。
在实验性牙龈炎期间，所有受试者的菌斑和出血评分显著增加，在重新进行口腔卫生程序后随后显著降低。蛋白质浓度、胱抑素活性和胱抑素C浓度未观察到显著变化。这些唾液参数与探诊出血之间未发现显著关系。
本研究证实了Lie等人（2001年）的早期结果，即在实验性牙龈炎期间和之后，唾液胱抑素活性和胱抑素C浓度没有显著变化。
