Yang C, Yifan L, Dan L, Qian Y, Ming-yan J
Department of Pharmacy, the First Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Pharmacy, the Affiliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning, China.
Drug Res (Stuttg). 2015 Dec;65(12):668-71. doi: 10.1055/s-0035-1547253. Epub 2015 May 13.
At present, most of the lipid-lowering drugs are western medicines, which have a lot of adverse reactions. Zhucha, an age-old Uyghur medicine, is made up of bamboo leaves and tea (green tea), which has good efficacy and lipid-lowering effect. The purpose of this study was to undertake a pharmacodynamic examination of the optimal proportions of bamboo leaf flavones and tea polyphenols required to achieve lipid lowering in rats. A hyperlipidemia rat model was used to examine the lipid lowering effects of bamboo leaf flavones and tea polyphenols. Wistar rats were divided into 13 groups including one hyperlipidemia model group and 2 positive drug groups as well as experimental groups (9 groups dosed with different proportions of bamboo leaf flavones and tea polyphenols, the 3 dosages of bamboo leaf flavones were 75 mg/kg/d, 50 mg/kg/d and 25 mg/kg/d respectively, the 3 dosages of tea polyphenol were 750 mg/kg/d, 500 mg/kg/d and 250 mg/kg/d). The weight, the levels of triglyceride (TG) and high-density lipoprotein cholesterol (HDL) were determined. A high dose of bamboo leaf flavones (75 mg/kg/d) combined with a medium dose of tea polyphenols (500 mg/kg/d) was deemed to be optimal for achieving a lipid-lowering effect, the weight had the smallest increase and the level of TG and HDL was similar to positive control. The bamboo leaf flavones and tea polyphenols were mixed according to a certain proportion (1:6.7), and the mixture achieved a lipid-lowering effect and might prove to be useful as a natural lipid-lowering agent.
目前，大多数降脂药物都是西药，存在很多不良反应。维吾尔族的传统药物竹茶，由竹叶和茶（绿茶）制成，具有良好的功效和降脂作用。本研究的目的是对大鼠降脂所需的竹叶黄酮和茶多酚的最佳比例进行药效学研究。采用高脂血症大鼠模型来研究竹叶黄酮和茶多酚的降脂效果。将Wistar大鼠分为13组，包括1个高脂血症模型组、2个阳性药物组和实验组（9组给予不同比例的竹叶黄酮和茶多酚，竹叶黄酮的3种剂量分别为75mg/kg/d、50mg/kg/d和25mg/kg/d，茶多酚的3种剂量分别为750mg/kg/d、500mg/kg/d和250mg/kg/d）。测定大鼠体重、甘油三酯（TG）水平和高密度脂蛋白胆固醇（HDL）水平。高剂量竹叶黄酮（75mg/kg/d）与中剂量茶多酚（500mg/kg/d）组合被认为是实现降脂效果的最佳组合，体重增加最小，TG和HDL水平与阳性对照相似。竹叶黄酮和茶多酚按一定比例（1:6.7）混合，该混合物具有降脂作用，可能是一种有用的天然降脂剂。
