Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, U.P., India.
Phytomedicine. 2012 Nov 15;19(14):1245-9. doi: 10.1016/j.phymed.2012.09.001. Epub 2012 Oct 16.
In continuation of our drug discovery program on Indian medicinal plants, we isolated bioactive compounds (1-5) from the leaves of Calophyllum inophyllum and evaluated their antidyslipidemic activity in triton induced hyperlipidemia model. The calophyllic acid (1A) and isocalophyllic acid (1B) mixture, canophyllic acid (4) and amentoflavone (5) showed dose dependent lipid lowering activity in in vivo experiments. The compounds 1A+1B mixture and 3 also showed good in vitro antioxidant activity.
在我们对印度药用植物的药物发现计划的延续中，我们从依兰叶中分离出具有生物活性的化合物（1-5），并评估了它们在三丁酸甘油酯诱导的高脂血症模型中的抗血脂作用。在体内实验中，金壳楠酸（1A）和异金壳楠酸（1B）混合物、Canophyllic 酸（4）和黄杨黄素（5）显示出剂量依赖性的降血脂活性。化合物 1A+1B 混合物和 3 还表现出良好的体外抗氧化活性。
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