Spang Anne
Growth and Development, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Mol Biol Cell. 2015 May 15;26(10):1783-5. doi: 10.1091/mbc.E14-11-1511.
This year marks the 35th anniversary of the isolation of 23 SEC genes. These genes all encode key regulators of the secretory pathway, and much of our knowledge of the secretory pathway is based on this initial discovery. The identification of the SEC genes is a result of combining genetics, biochemistry, and electron microscopy in a very clever way. Scientists have been busy ever since seeking to understand the function and regulation of these genes and to identify further key players in the process. Although most of the machinery acting along the secretory pathway is known and its function generally understood, knowledge of regulation of the pathway under various conditions is still scarce and will keep researchers busy for years to come.
今年是23个SEC基因被分离出来35周年。这些基因都编码分泌途径的关键调节因子，我们对分泌途径的许多了解都基于这一最初的发现。SEC基因的鉴定是巧妙地将遗传学、生物化学和电子显微镜相结合的结果。从那以后，科学家们一直忙于试图了解这些基因的功能和调控，并识别该过程中的其他关键参与者。尽管沿分泌途径发挥作用的大多数机制已为人所知，其功能也大致清楚，但在各种条件下该途径的调控知识仍然匮乏，未来几年仍将让研究人员忙碌不已。
