长链非编码RNA在基因组形成与表达中的作用。

Angrand Pierre-Olivier, Vennin Constance, Le Bourhis Xuefen, Adriaenssens Eric

Cell Plasticity and Cancer - Inserm U908, University of Lille Lille, France.

Front Genet. 2015 Apr 29;6:165. doi: 10.3389/fgene.2015.00165. eCollection 2015.

Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation, and post-transcriptional control. Misregulation of lncRNAs expression has been found to be associated to cancer and other human disorders. Here, we review the different types of lncRNAs, their mechanisms of action on genome formatting and expression and emphasized on the multifaceted action of the H19 lncRNA.

长链非编码RNA（lncRNAs）是一类没有蛋白质编码潜能但在众多生物学功能中起关键作用的转录本。长链非编码RNA在基因表达的不同水平发挥调节作用，包括染色质组织、转录调控和转录后控制。lncRNAs表达失调已被发现与癌症和其他人类疾病相关。在此，我们综述了不同类型的lncRNAs、它们对基因组形成和表达的作用机制，并着重介绍了H19 lncRNA的多方面作用。