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长链非编码RNA在基因组形成与表达中的作用。

The role of long non-coding RNAs in genome formatting and expression.

作者信息

Angrand Pierre-Olivier, Vennin Constance, Le Bourhis Xuefen, Adriaenssens Eric

机构信息

Cell Plasticity and Cancer - Inserm U908, University of Lille Lille, France.

出版信息

Front Genet. 2015 Apr 29;6:165. doi: 10.3389/fgene.2015.00165. eCollection 2015.

DOI:10.3389/fgene.2015.00165
PMID:25972893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4413816/
Abstract

Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation, and post-transcriptional control. Misregulation of lncRNAs expression has been found to be associated to cancer and other human disorders. Here, we review the different types of lncRNAs, their mechanisms of action on genome formatting and expression and emphasized on the multifaceted action of the H19 lncRNA.

摘要

长链非编码RNA（lncRNAs）是一类没有蛋白质编码潜能但在众多生物学功能中起关键作用的转录本。长链非编码RNA在基因表达的不同水平发挥调节作用，包括染色质组织、转录调控和转录后控制。lncRNAs表达失调已被发现与癌症和其他人类疾病相关。在此，我们综述了不同类型的lncRNAs、它们对基因组形成和表达的作用机制，并着重介绍了H19 lncRNA的多方面作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/5748dd03bfc3/fgene-06-00165-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/b078551954d8/fgene-06-00165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/c3a31ca0e10f/fgene-06-00165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/48019c24c7f0/fgene-06-00165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/19e3ff0a7079/fgene-06-00165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/5748dd03bfc3/fgene-06-00165-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/b078551954d8/fgene-06-00165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/c3a31ca0e10f/fgene-06-00165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/48019c24c7f0/fgene-06-00165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/19e3ff0a7079/fgene-06-00165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ee2/4413816/5748dd03bfc3/fgene-06-00165-g005.jpg

相似文献

[1]
The role of long non-coding RNAs in genome formatting and expression.

Front Genet. 2015-4-29

[2]
Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels.

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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
Classification and experimental identification of plant long non-coding RNAs.

Genomics. 2018-4-19

[10]
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BMC Genomics. 2018-9-18

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[3]
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[4]
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Noncoding RNA Res. 2024-5-20

[5]
Natural antisense transcripts as versatile regulators of gene expression.

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[6]
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Cancer Pathog Ther. 2022-12-24

[7]
The Impact of Long Noncoding RNAs in Tissue Regeneration and Senescence.

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[8]
The role of long non-coding RNA in abdominal aortic aneurysm.

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[9]
Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer.

Noncoding RNA. 2023-3-9

[10]
restoration via  long-noncoding RNA CRISPR-targeting suppresses metastasis in triple-negative breast cancer.

Proc Natl Acad Sci U S A. 2023-3-14

本文引用的文献

[1]
Diverse involvement of EZH2 in cancer epigenetics.

Am J Transl Res. 2015-2-15

[2]
A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.

Cell. 2015-2-12

[3]
miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction.

Nat Chem Biol. 2014-12-22

[4]
In vivo activation of a conserved microRNA program induces mammalian heart regeneration.

Cell Stem Cell. 2014-11-6

[5]
Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner.

Oncotarget. 2015-1-1

[6]
Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1.

Genes Cells. 2014-9

[7]
Small RNAs: the qualified candidates for gene manipulation in diverse clinical pathologies.

Crit Rev Ther Drug Carrier Syst. 2014

[8]
Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease.

Front Genet. 2014-6-6

[9]
H19 promotes pancreatic cancer metastasis by derepressing let-7's suppression on its target HMGA2-mediated EMT.

Tumour Biol. 2014-9

[10]
Lentivirus-mediated RNA interference targeting the long noncoding RNA HOTAIR inhibits proliferation and invasion of endometrial carcinoma cells in vitro and in vivo.

Int J Gynecol Cancer. 2014-5

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