植物长非编码 RNA 的分类与实验鉴定。

Classification and experimental identification of plant long non-coding RNAs.

机构信息

Department of Biology, SBA School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan.

Department of Plant, Soil and Agricultural Systems, Southern Illinois University Carbondale, USA.

出版信息

Genomics. 2019 Sep;111(5):997-1005. doi: 10.1016/j.ygeno.2018.04.014. Epub 2018 Apr 19.

DOI:10.1016/j.ygeno.2018.04.014

PMID:29679643

Abstract

Our understanding of gene regulation is constantly evolving. It is now clear that the majority of cellular transcripts are non-coding RNAs. The spectrum of non-coding RNAs is diverse and includes short (<200 nt) and long non-coding RNAs (lncRNAs) (>200 nt). LncRNAs regulate gene expression through diverse mechanisms. In this review, we describe the emerging roles of lncRNA mediated plant gene regulation. We discuss the current classification of lncRNAs and their role in genome organization and gene regulation. We also highlight a subset of lncRNAs that are epigenetic regulators of plant gene expression. Lastly, we provide an overview of emerging techniques and databases that are employed for the identification and characterization of plant lncRNAs.

摘要

我们对基因调控的理解在不断发展。现在很清楚，大多数细胞转录物是非编码 RNA。非编码 RNA 的范围多种多样，包括短(<200nt)和长非编码 RNA (lncRNA)(>200nt)。lncRNA 通过多种机制调节基因表达。在这篇综述中，我们描述了 lncRNA 介导的植物基因调控的新作用。我们讨论了 lncRNA 的当前分类及其在基因组组织和基因调控中的作用。我们还强调了一组 lncRNA 作为植物基因表达的表观遗传调节剂。最后，我们概述了用于鉴定和表征植物 lncRNA 的新兴技术和数据库。