Nascimento Henrique, Alves Ana Inês, Coimbra Susana, Catarino Cristina, Gomes Diana, Bronze-da-Rocha Elsa, Costa Elísio, Rocha-Pereira Petronila, Aires Luísa, Mota Jorge, Ferreira Mansilha Helena, Rêgo Carla, Santos-Silva Alice, Belo Luís
Instituto de Biologia Molecular e Celular (Institute for Molecular and Cell Biology), Universidade do Porto, Porto, Portugal ; Instituto de Investigaçãoe Inovação em Saúde (Institute for Research and Innovation in Health), Universidade do Porto, Porto, Portugal ; Biological Science Department, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Instituto de Biologia Molecular e Celular (Institute for Molecular and Cell Biology), Universidade do Porto, Porto, Portugal ; Instituto de Investigaçãoe Inovação em Saúde (Institute for Research and Innovation in Health), Universidade do Porto, Porto, Portugal.
Diabetol Metab Syndr. 2015 Jan 23;7:4. doi: 10.1186/1758-5996-7-4. eCollection 2015.
Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation, in young obese individuals.
125 obese patients (13.4 years; 53.6% females) were studied. TB, lipid profile including Ox-LDL, markers of glucose metabolism, and levels of C-reactive protein (CRP) and adiponectin were determined. Anthropometric data was also collected. In all patients, Ox-LDL correlated positively with BMI, total cholesterol, LDLc, triglycerides (TG), CRP, glucose, insulin and HOMAIR; while inversely with TB and HDLc/Total cholesterol ratio (P < 0.05 for all). In multiple linear regression analysis, LDLc, TG, HDLc and TB levels were significantly associated with Ox-LDL (standardized Beta: 0.656, 0.293, -0.283, -0.164, respectively; P < 0.01 for all). After removing TG and HDLc from the analysis, HOMAIR was included in the regression model. In this new model, LDLc remained the best predictor of Ox-LDL levels (β = 0.665, P < 0.001), followed by TB (β = -0.202, P = 0.002) and HOMAIR (β = 0.163, P = 0.010).
Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk.
胆红素在体外可预防脂质氧化，但体内与氧化型低密度脂蛋白（Ox-LDL）水平的关联研究较少。我们的目的是研究年轻肥胖个体中Ox-LDL与总胆红素（TB）水平以及与代谢综合征和炎症相关变量之间的关联。
对125例肥胖患者（年龄13.4岁；53.6%为女性）进行了研究。测定了TB、包括Ox-LDL在内的血脂谱、葡萄糖代谢指标以及C反应蛋白（CRP）和脂联素水平。还收集了人体测量数据。在所有患者中，Ox-LDL与BMI、总胆固醇、低密度脂蛋白胆固醇（LDLc）、甘油三酯（TG）、CRP、葡萄糖、胰岛素和稳态模型评估的胰岛素抵抗指数（HOMAIR）呈正相关；而与TB和高密度脂蛋白胆固醇/总胆固醇比值呈负相关（所有P均<0.05）。在多元线性回归分析中，LDLc、TG、高密度脂蛋白胆固醇（HDLc）和TB水平与Ox-LDL显著相关（标准化β分别为0.656、0.293、-0.283、-0.164；所有P均<0.01）。从分析中去除TG和HDLc后，将HOMAIR纳入回归模型。在这个新模型中，LDLc仍然是Ox-LDL水平的最佳预测指标（β = 0.665，P < 0.001），其次是TB（β = -0.202，P = 0.002）和HOMAIR（β = 0.163，P = 0.010）。
较低的胆红素水平可能导致肥胖儿童和青少年的LDL氧化增加，从而增加心血管疾病风险。
