Department of Stomatology, First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Endocrinology and Metabolism, Fourth People's Hospital of Shenyang, Shenyang, China.
PeerJ. 2024 Mar 28;12:e17187. doi: 10.7717/peerj.17187. eCollection 2024.
Periodontitis is a chronic inflammatory disease caused by bacterial infection in the periodontal support tissue. Visfatin, a hormone secreted mainly by adipocytes and macrophages, plays an important role in immune regulation and defense. Although studies have indicated that patients with periodontitis have significantly high serum and gingival crevicular fluid levels of visfatin, the relationship between this adipocytokine and periodontal disease remains unclear.
The aim of this study was to systematically evaluate the association between visfatin levels and periodontitis.
The PubMed, Web of Science, ScienceDirect, EBSCO, and Wiley Online Library databases were searched for potential studies, using "periodontitis" and "visfatin" as the keywords in the title and abstract search fields. Standardized mean difference (SMD) values with corresponding 95% confidence intervals (CIs) were determined from the results of this meta-analysis.
In total, 22 articles involving 456 patients with periodontitis and 394 healthy individuals (controls) were included in the meta-analysis. Visfatin levels were significantly higher in the patients with periodontitis than in the healthy individuals (SMD: 3.82, 95% CI [3.01-4.63]). Moreover, the visfatin levels were significantly lowered after periodontitis treatment (SMD: -2.29, 95% CI [-3.33 to -1.26]).
This first-ever meta-analysis comparing visfatin levels between patients with periodontitis and healthy individuals suggests that this adipocytokine can be a diagnostic and therapeutic biomarker for periodontal disease.
牙周炎是一种由牙周组织支持组织中的细菌感染引起的慢性炎症性疾病。内脏脂肪素是一种主要由脂肪细胞和巨噬细胞分泌的激素，在免疫调节和防御中起着重要作用。尽管研究表明，牙周炎患者的血清和龈沟液中的内脏脂肪素有显著升高，但这种脂肪细胞因子与牙周病的关系尚不清楚。
本研究旨在系统评估内脏脂肪素水平与牙周炎的关系。
在 PubMed、Web of Science、ScienceDirect、EBSCO 和 Wiley Online Library 数据库中，以“牙周炎”和“内脏脂肪素”作为标题和摘要搜索字段的关键词，搜索可能的研究。从荟萃分析的结果中确定标准化均数差（SMD）值及其相应的 95%置信区间（CI）。
共纳入 22 篇文章，涉及 456 例牙周炎患者和 394 例健康个体（对照组）。牙周炎患者的内脏脂肪素水平明显高于健康个体（SMD：3.82，95%CI[3.01-4.63]）。此外，牙周炎治疗后内脏脂肪素水平显著降低（SMD：-2.29，95%CI[-3.33 至-1.26]）。
这是首次比较牙周炎患者和健康个体内脏脂肪素水平的荟萃分析，表明该脂肪细胞因子可作为牙周病的诊断和治疗生物标志物。
