The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 41345, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Department of Pediatrics, Hallands Hospital Halmstad, 30185 Halmstad, Sweden; Göteborg Paediatric Growth Research Center, Department of Paediatrics, the University of Gothenburg, Queen Silvia Children's Hospital, 416 85 Gothenburg.
Cell Host Microbe. 2015 May 13;17(5):690-703. doi: 10.1016/j.chom.2015.04.004.
The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assessed the impact of mode of delivery and feeding on its establishment. In contrast to vaginally delivered infants, the gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers. Nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota. Microbiota composition and ecological network had distinctive features at each sampled stage, in accordance with functional maturation of the microbiome. Our findings establish a framework for understanding the interplay between the gut microbiome and the human body in early life.
肠道微生物群对人类健康至关重要，但它在生命早期的建立尚未被定量和功能上进行研究。我们应用宏基因组分析方法对来自瑞典大量婴儿及其母亲的粪便样本进行分析，描述了生命第一年的肠道微生物组，并评估了分娩方式和喂养方式对其建立的影响。与阴道分娩的婴儿相比，剖宫产分娩的婴儿的肠道微生物组与其母亲的肠道微生物组的相似性明显较低。营养对早期微生物组组成和功能有重大影响，停止母乳喂养而不是引入固体食物是使微生物组成熟为成人样微生物组所必需的。在每个采样阶段，微生物组组成和生态网络都具有独特的特征，这与微生物组的功能成熟相对应。我们的研究结果为理解生命早期肠道微生物组与人体之间的相互作用提供了一个框架。
