CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
University of Chinese Academy of Sciences, Beijing, China.
Gut Microbes. 2023 Jan-Dec;15(1):2231596. doi: 10.1080/19490976.2023.2231596.
The gut microbiota is involved in the production of numerous metabolites that maintain host wellbeing. The assembly of the gut microbiome is highly dynamic, and influenced by many postnatal factors, moreover, little is known about the development of the gut metabolome. We showed that geography has an important influence on the microbiome dynamics in the first year of life based on two independent cohorts from China and Sweden. Major compositional differences since birth were the high relative abundance of in the Swedish cohort and in the Chinese cohort. We analyzed the development of the fecal metabolome in the first year of life in the Chinese cohort. Lipid metabolism, especially acylcarnitines and bile acids, was the most abundant metabolic pathway in the newborn gut. Delivery mode and feeding induced particular differences in the gut metabolome since birth. In contrast to C-section newborns, medium- and long-chain acylcarnitines were abundant at newborn age only in vaginally delivered infants, associated by the presence of bacteria such as and . Our data provide a basis for understanding the maturation of the fecal metabolome and the metabolic role of gut microbiota in infancy.
肠道微生物群参与了许多代谢物的产生，这些代谢物维持着宿主的健康。肠道微生物组的组装是高度动态的，受许多产后因素的影响，此外，人们对肠道代谢组的发展知之甚少。我们基于来自中国和瑞典的两个独立队列表明，地理对生命第一年的微生物组动态有重要影响。自出生以来的主要组成差异是瑞典队列中相对丰度较高，而中国队列中相对丰度较高。我们分析了中国队列中生命第一年粪便代谢组的发展。脂质代谢，特别是酰基辅酶 A 和胆汁酸，是新生肠道中最丰富的代谢途径。分娩方式和喂养方式自出生以来就诱导了肠道代谢组的特殊差异。与剖宫产新生儿相比，只有阴道分娩的婴儿在新生儿期才有中长链酰基辅酶 A 丰富，这与细菌的存在有关，如 和 。我们的数据为理解粪便代谢组的成熟和肠道微生物在婴儿期的代谢作用提供了基础。
