Lim Anthony Tien Hoe, Clucas Danielle, Khoo Christine, Parameswaran Bimal Kumar, Lau Eddie
Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
J Med Imaging Radiat Oncol. 2016 Feb;60(1):92-5. doi: 10.1111/1754-9485.12321. Epub 2015 May 13.
Neurolymphomatosis (NL) is a rare presentation of lymphoma or leukemic infiltration of cranial or peripheral nerves. It is distinct from subarachnoid seeding of lymphoma as well as perineural tumour seen in epidural lymphoma. This rare condition has been reported mainly in oncology literature. Imaging features of solitary nerve involvement mimics, among others, peripheral nerve sheath tumours. We present the MRI and (18) fluorodeoxyglucose positron emission tomography ((18) FDG-PET) features of three cases of NL. MRI demonstrated variable appearances: infiltrative mass displacing neural fascicles, diffuse thickening and enhancement, and thickening of individual neural fascicles. (18) FDG-PET demonstrated avid uptake in all cases, two of which revealed skip lesions of the same nerve. The diagnosis of NL was confirmed by uncomplicated CT-guided biopsy of the affected sciatic nerve in one patient.
神经淋巴瘤（NL）是淋巴瘤或白血病浸润颅神经或周围神经的一种罕见表现形式。它与淋巴瘤的蛛网膜下腔播散以及硬膜外淋巴瘤中所见的神经周围肿瘤不同。这种罕见病症主要在肿瘤学文献中有所报道。孤立性神经受累的影像学特征，其中包括，可模仿周围神经鞘瘤。我们展示了3例神经淋巴瘤的MRI和（18）氟脱氧葡萄糖正电子发射断层扫描（（18）FDG-PET）特征。MRI表现多样：浸润性肿块使神经束移位、弥漫性增厚及强化，以及单个神经束增厚。（18）FDG-PET在所有病例中均显示摄取增加，其中2例显示同一神经的跳跃性病变。1例患者通过对受影响的坐骨神经进行无并发症的CT引导活检确诊为神经淋巴瘤。
