Sheean Patricia, Kabir Christopher, Rao Ruta, Hoskins Kent, Stolley Melinda
J Acad Nutr Diet. 2015 Oct;115(10):1690-8. doi: 10.1016/j.jand.2015.03.017. Epub 2015 May 12.
Historically, women with metastatic breast cancer are excluded from lifestyle interventions under the assumptions that diet and physical activity will have little impact on their disease trajectory. However, recent treatment advances have led to significant increases in survivorship that pose challenges to this assumption.
The objectives of this study were to measure dietary intake, physical functioning, and quality of life in a subset of women with metastatic breast cancer, and to inform future interventions in this growing population.
Demographics, clinical characteristics, dietary intake, physical functioning, and quality of life were examined cross-sectionally using validated methodologies.
PARTICIPANTS/SETTING: Twenty-five women with metastatic breast cancer were recruited during a 4-month period (June 2014 to September 2014) from two university hospitals in the Midwest that serve an ethnically diverse patient population. Women completed questionnaires and 24-hour dietary recalls (1 weekday, 1 weekend).
Lifestyle habits were analyzed.
Means (±standard deviations) and frequencies were tallied and t tests were conducted.
On average, participants were 58.8 (±12.8) years of age, predominantly minority, had been living with metastatic breast cancer for a mean of 36.9 (±29.3) months, and exhibited significant nutrition-impact symptomology (eg, pain, dry mouth, fatigue). Bone and lung were the most common sites of metastases. Compared to a larger, normative sample of women with metastatic breast cancer, study participants displayed similar physical (P=0.61) and functional well-being scores (P=0.76), but higher social (P=0.10) and emotional well-being scores (P<0.01). The analyses of lifestyle factors showed that the majority of women were overweight or obese (n=14), not routine exercisers (n=15), and had dietary patterns high in fat and low in fiber.
This study supports that many women with metastatic breast cancer are in need of carefully tailored, evidence-based lifestyle strategies that address symptom burden, including weight management. The implications of diet and physical activity on quality of life in this population remain unexplored.
从历史上看，转移性乳腺癌女性被排除在生活方式干预之外，原因是人们认为饮食和体育活动对她们的疾病进程影响不大。然而，最近的治疗进展使生存期显著延长，这对这一假设提出了挑战。
本研究的目的是测量一部分转移性乳腺癌女性的饮食摄入量、身体功能和生活质量，并为这一不断增长的人群的未来干预提供信息。
使用经过验证的方法对人口统计学、临床特征、饮食摄入量、身体功能和生活质量进行横断面研究。
参与者/研究地点：在2014年6月至2014年9月的4个月期间，从美国中西部的两家大学医院招募了25名转移性乳腺癌女性，这两家医院服务的患者群体种族多样。女性完成了问卷调查和24小时饮食回忆（1个工作日、1个周末）。
对生活方式习惯进行了分析。
计算均值（±标准差）和频率，并进行t检验。
参与者平均年龄为58.8（±12.8）岁，主要为少数族裔，患有转移性乳腺癌的时间平均为36.9（±29.3）个月，并表现出明显的营养影响症状（如疼痛、口干、疲劳）。骨和肺是最常见的转移部位。与更大规模的转移性乳腺癌女性标准样本相比，研究参与者的身体（P=0.61）和功能幸福感得分相似（P=0.76），但社会（P=0.10）和情感幸福感得分更高（P<0.01）。生活方式因素分析表明，大多数女性超重或肥胖（n=14），不是常规锻炼者（n=15），饮食模式高脂肪、低纤维。
本研究支持许多转移性乳腺癌女性需要精心定制的、基于证据的生活方式策略来应对症状负担，包括体重管理。饮食和体育活动对该人群生活质量的影响仍有待探索。
