Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Int J Infect Dis. 2015 Jul;36:6-8. doi: 10.1016/j.ijid.2015.05.008. Epub 2015 May 11.
Human parechovirus (HPeV) belongs to the Picornaviridae family of RNA viruses. HPeV infections can be asymptomatic, lead to mild respiratory and/or gastrointestinal symptoms, or less frequently cause severe diseases such as sepsis, meningitis, encephalitis, and myocarditis. Severe neurological HPeV infections occur most commonly in infants and neonates. There are currently 16 recognized types of HPeV. HPeV type 3 (HPeV3) has been the predominant type associated with severe central nervous system disease in neonates and newborns since its discovery in 1999. Although HPeV-related infections have been reported in adults, symptomatic HPeV3 infections in adolescents and adults are uncommon. A case of severe HPeV3 myocarditis and encephalitis in an adolescent is described.
人类肠道病毒（HPeV）属于 RNA 病毒的小核糖核酸病毒科。HPeV 感染可以无症状，导致轻度呼吸道和/或胃肠道症状，或较不常见地导致严重疾病，如败血症、脑膜炎、脑炎和心肌炎。严重的神经 HPeV 感染最常见于婴儿和新生儿。目前已发现 16 种 HPeV 类型。自 1999 年发现以来，HPeV 型 3（HPeV3）一直是与新生儿和新生儿严重中枢神经系统疾病相关的主要类型。尽管已经在成年人中报告了与 HPeV 相关的感染，但青少年和成年人的有症状 HPeV3 感染并不常见。描述了一例青少年严重 HPeV3 心肌炎和脑炎病例。
