Coste V, Schweitzer C, Paya C, Touboul D, Korobelnik J-F
Service d'ophtalmologie, CHU Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France; Université Bordeaux 2 Victor-Segalen, 146, rue Léo-Saignat, 33000 Bordeaux, France.
Service d'ophtalmologie, CHU Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France; Université Bordeaux 2 Victor-Segalen, 146, rue Léo-Saignat, 33000 Bordeaux, France.
J Fr Ophtalmol. 2015 Jun;38(6):504-13. doi: 10.1016/j.jfo.2015.01.007. Epub 2015 May 11.
To compare corneal biomechanical properties measured with Corvis Scheimpflug technology (Corvis ST) between a group of patients with chronic open-angle glaucoma and a group of control patients.
Prospective observational case-control study.
This study enrolled 56 right eyes of 56 patients (G1 [chronic open-angle glaucoma] n=37/G2 [control] n=19). Each patient underwent measurement of corneal biomechanical properties by dynamic Scheimpflug (Corvis ST) camera and the Ocular Response Analyser (ORA), then a measurement of intraocular pressure (IOP) by Goldmann applanation tonometry (GAT) and measurement of central corneal thickness (CCT) by optical coherence tomography during the same visit, by a single clinician. The parameters determined by Corvis ST are: Corvis IOP (IOP Corvis ST), the corneal deformation amplitude (CDA), corneal velocity, the time at highest concavity (TIME CONCAV), the lengths of applanation and their corresponding applanation time. Those studied by ORA are: compensated IOP (IOPcc), non-compensated IOL (IOPg), corneal hysteresis (CH) and corneal resistance factor (CRF).
IOP measured on all patients by Corvis ST was positively correlated to GAT (Spearman r=0.569, P<0.001) and PIOcc (Spearman r=0.531, P<0.001). After adjusting for age effect, CCT and GAT, the CDA was significantly lower in G1 than in G2, respectively 1.10 ± 0.12 mm and 1.15 ± 0.10mm (P<0.001). The TIME CONCAV is significantly shorter in G1 than in G2, respectively 16.88 ± 0.63 ms and 17.11 ± 0.29 ms, P=0.029. CH was significantly lower in G1 (G1: 9.58 ± 1.94 than G2: 10.89 ± 2.16, P=0.026).
This study showed differences in corneal biomechanical properties between glaucoma and control patients. The cornea of glaucoma patients appears less deformable.
比较一组慢性开角型青光眼患者和一组对照患者使用Corvis Scheimpflug技术（Corvis ST）测量的角膜生物力学特性。
前瞻性观察性病例对照研究。
本研究纳入了56例患者的56只右眼（G1组[慢性开角型青光眼]n = 37 / G2组[对照]n = 19）。每位患者在同一次就诊时由一名临床医生通过动态Scheimpflug（Corvis ST）相机和眼反应分析仪（ORA）测量角膜生物力学特性，然后通过Goldmann压平眼压计（GAT）测量眼压（IOP），并通过光学相干断层扫描测量中央角膜厚度（CCT）。Corvis ST测定的参数包括：Corvis眼压（IOP Corvis ST）、角膜变形幅度（CDA）、角膜速度、最高凹陷时间（TIME CONCAV）、压平长度及其相应的压平时间。ORA研究的参数包括：补偿眼压（IOPcc）、未补偿眼压（IOPg）、角膜滞后（CH）和角膜阻力因子（CRF）。
Corvis ST测量的所有患者眼压与GAT（Spearman r = 0.569，P < 0.001）和PIOcc（Spearman r = 0.531，P < 0.001）呈正相关。在调整年龄、CCT和GAT的影响后，G1组的CDA显著低于G2组，分别为1.10±0.12mm和1.15±0.10mm（P < 0.001）。G1组的TIME CONCAV显著短于G2组，分别为16.88±0.63ms和17.11±0.29ms，P = 0.029。G1组的CH显著低于G2组（G1：9.58±1.94，G2：10.89±2.16，P = 0.026）。
本研究显示青光眼患者与对照患者的角膜生物力学特性存在差异。青光眼患者的角膜似乎变形性较小。
