Dowd T L, Kaplan B A, Gupta R K, Aisen P
Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University, New York, New York 10469.
Magn Reson Med. 1987 Oct;5(4):395-7. doi: 10.1002/mrm.1910050414.
Average linewidths of methyl and methylene proton resonances of plasma lipoproteins from healthy controls and untreated cancer patients were measured in water-suppressed proton spectra obtained at 400 MHz. In contrast to a previous report (E. T. Fossel, J. M. Carr, and J. McDonagh, N. Engl. J. Med. 315, 1369 (1986] no statistically significant difference (P greater than 0.5) was found between the average linewidths in plasma samples from 20 normal controls (36.0 +/- 6.4 Hz) and 17 untreated cancer patients (34.6 +/- 6.3 Hz). When the effect of lactate was removed by graphical extrapolation, a small but marginally significant (P = 0.08) difference was observed between the average linewidths of the normal controls (35.1 +/- 5.8 Hz) and untreated cancer patients (31.8 +/- 5.2 Hz). However, there was still a large overlap between the two groups. In addition, substantial day to day variations in the linewidths of samples from the same individuals were observed. We conclude that these measurements cannot be used to detect cancer.
在400MHz获得的水抑制质子谱中，测量了健康对照者和未经治疗的癌症患者血浆脂蛋白的甲基和亚甲基质子共振的平均线宽。与之前的一份报告（E.T. Fossel、J.M. Carr和J. McDonagh，《新英格兰医学杂志》315, 1369 (1986)）相反，在20名正常对照者（36.0±6.4Hz）和17名未经治疗的癌症患者（34.6±6.3Hz）的血浆样本平均线宽之间未发现统计学上的显著差异（P大于0.5）。当通过图形外推法去除乳酸的影响后，正常对照者（35.1±5.8Hz）和未经治疗的癌症患者（31.8±5.2Hz）的平均线宽之间观察到一个小但边缘显著（P = 0.08）的差异。然而，两组之间仍有很大的重叠。此外，观察到来自同一个体的样本线宽存在显著的每日变化。我们得出结论，这些测量不能用于检测癌症。
