Elworthy P, Hitchcock E
Department of Neurochemistry, University of Birmingham, U.K.
Biochim Biophys Acta. 1989 Dec 8;993(2-3):212-6. doi: 10.1016/0304-4165(89)90166-9.
Interpretation of polyamine levels found in the tissues and red blood cells of tumour patients has been plagued by the wide variations seen in the concentrations when estimated in groups of either tumour or control patients. To ascertain whether the patient's age or sex were contributing factors, red blood cell polyamine concentrations of 117 control patients were examined by high-performance liquid chromatography. Concentrations of spermidine were consistently higher than those of spermine. Also, regression analysis showed that spermidine and spermine levels tended to change with age and sex, though these trends were statistically non-significant.
肿瘤患者组织和红细胞中多胺水平的解读一直受到困扰，因为在肿瘤患者组或对照组中进行浓度估计时，会出现很大的差异。为了确定患者的年龄或性别是否是影响因素，采用高效液相色谱法检测了117名对照患者的红细胞多胺浓度。亚精胺的浓度始终高于精胺。此外，回归分析表明，亚精胺和精胺水平随年龄和性别有变化趋势，尽管这些趋势在统计学上无显著意义。
