Travers R J, Smith S A, Morrissey J H
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Int J Lab Hematol. 2015 May;37 Suppl 1(0 1):31-5. doi: 10.1111/ijlh.12349.
While we have understood the basic outline of the enzymes and reactions that make up the traditional blood coagulation cascade for many years, recently our appreciation of the complexity of these interactions has greatly increased. This has resulted in unofficial 'revisions' of the coagulation cascade to include new amplification pathways and connections between the standard coagulation cascade enzymes, as well as the identification of extensive connections between the immune system and the coagulation cascade. The discovery that polyphosphate is stored in platelet dense granules and is secreted during platelet activation has resulted in a recent burst of interest in the role of this ancient molecule in human biology. Here we review the increasingly complex role of platelet polyphosphate in hemostasis, thrombosis, and inflammation that has been uncovered in recent years, as well as novel therapeutics centered on modulating polyphosphate's roles in coagulation and inflammation.
多年来，我们已经了解了构成传统血液凝固级联反应的酶和反应的基本概况，但最近我们对这些相互作用的复杂性的认识有了极大提高。这导致了对凝血级联反应的非官方“修订”，包括新的放大途径以及标准凝血级联反应酶之间的联系，同时也发现了免疫系统与凝血级联反应之间的广泛联系。多聚磷酸盐储存在血小板致密颗粒中并在血小板激活时分泌这一发现，引发了近期人们对这种古老分子在人类生物学中作用的浓厚兴趣。在此，我们综述近年来发现的血小板多聚磷酸盐在止血、血栓形成和炎症中日益复杂的作用，以及以调节多聚磷酸盐在凝血和炎症中的作用为中心的新型疗法。
