Zhang Yan, Xia Zu-Guang, Zhu Jin-Hong, Chen Min-Bin, Wang Tong-Min, Shen Wen-Xiang, He Jing
Department of Medical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, 215300, Jiangsu, China.
Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Mol Genet Genomics. 2015 Dec;290(6):2063-73. doi: 10.1007/s00438-015-1058-y. Epub 2015 May 15.
A number of studies have investigated the associations between IL-10 polymorphisms and non-Hodgkin lymphoma (NHL) susceptibility; however, the conclusions were still contradictory. To acquire a more precise estimation of the association, we performed the current meta-analysis. We systematically searched publications from EMBASE and MEDLINE, and calculated pooled odds ratios (ORs) and 95 % confidence intervals (CIs) using either fixed-effects or random-effects model. Genotype-based IL-10 mRNA expression analysis was performed using online public database of 270 individuals with three different ethnicities. A total of 10,703 cases and 11,823 controls from 10 studies were included for the -3575T>A polymorphism, 10,226 cases and 12,215 controls from 17 studies for the -1082A>G polymorphism. Pooled results indicated that IL-10 -3575T>A was associated with increased risk of diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL), especially for Caucasians and hospital-based population. There was no association between IL-10 -1082A>G and NHL risk. However, subgroup analysis showed that IL-10 -1082GG might confer increased susceptibility to FL. In summary, this meta-analysis indicated that -3575T>A polymorphism was associated with altered NHL susceptibility for Caucasians and hospital-based population, especially for DLBCL and FL subtypes. The -1082A>G polymorphism may contribute to increased FL risk. Further large-scale population studies among different ethnicities are needed to validate these results.
多项研究调查了白细胞介素-10（IL-10）基因多态性与非霍奇金淋巴瘤（NHL）易感性之间的关联；然而，结论仍相互矛盾。为了更精确地评估这种关联，我们进行了当前的荟萃分析。我们系统地检索了EMBASE和MEDLINE上的出版物，并使用固定效应或随机效应模型计算合并比值比（OR）和95%置信区间（CI）。使用包含270名不同种族个体的在线公共数据库进行基于基因型的IL-10 mRNA表达分析。纳入了10项研究中的10703例病例和11823例对照用于-3575T>A多态性分析，17项研究中的10226例病例和12215例对照用于-1082A>G多态性分析。合并结果表明，IL-10 -3575T>A与弥漫性大B细胞淋巴瘤（DLBCL）和滤泡性淋巴瘤（FL）风险增加相关，尤其是对白种人和基于医院的人群。IL-10 -1082A>G与NHL风险之间无关联。然而，亚组分析显示，IL-10 -1082GG可能会增加患FL的易感性。总之，这项荟萃分析表明，-3575T>A多态性与白种人和基于医院的人群中NHL易感性改变相关，尤其是对DLBCL和FL亚型。-1082A>G多态性可能会增加FL风险。需要进一步在不同种族中开展大规模人群研究以验证这些结果。
