Swafford Daniel, Manicassamy Santhakumar
Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Georgia Regents University, Augusta, GA 30912, USA.
Discov Med. 2015 Apr;19(105):303-10.
A fundamental puzzle in immunology is how the immune system launches robust immunity against pathogens while maintaining a state of tolerance to the body's own tissues and the trillions of commensal microorganisms and food antigens that confront them every day. Innate immune cells, such as dendritic cells (DCs) and macrophages, play a fundamental role in this process. Emerging studies have highlighted that the Wnt signaling pathway, particularly in DCs, plays a major role in regulating tolerance versus immunity. Here, we review our current understanding of how Wnt-signaling shapes the immune response and, in addition, highlight unanswered questions, the solution of which will be imperative in the rational exploitation of this pathway in vaccine design and immune therapy.
免疫学中的一个基本难题是，免疫系统如何在对病原体发动强大免疫的同时，维持对机体自身组织以及每天接触的数万亿共生微生物和食物抗原的耐受状态。天然免疫细胞，如树突状细胞（DCs）和巨噬细胞，在这一过程中发挥着重要作用。新出现的研究表明，Wnt信号通路，尤其是在DCs中，在调节耐受与免疫方面发挥着主要作用。在此，我们回顾了目前对Wnt信号如何塑造免疫反应的理解，此外，还强调了尚未解决的问题，解决这些问题对于在疫苗设计和免疫治疗中合理利用该信号通路至关重要。
