Hahn Jennifer Nancy, Kaushik Deepak Kumar, Yong V Wee
Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
Hotchkiss Brain Institute, University of Calgary, Alberta, Canada
J Leukoc Biol. 2015 Jul;98(1):33-48. doi: 10.1189/jlb.3RU0215-045R. Epub 2015 May 14.
EMMPRIN (CD147), originally described as an inducer of the expression of MMPs, has gained attention in its involvement in various immunologic diseases, such that anti-EMMPRIN antibodies are considered as potential therapeutic medications. Given that MMPs are involved in the pathogenesis of various disease states, it is relevant that targeting an upstream inducer would make for an effective therapeutic strategy. Additionally, EMMPRIN is now appreciated to have multiple roles apart from MMP induction, including in cellular functions, such as migration, adhesion, invasion, energy metabolism, as well as T cell activation and proliferation. Here, we review what is known about EMMPRIN in numerous immunologic/inflammatory disease conditions with a particular focus on its complex roles in T cell biology.
细胞外基质金属蛋白酶诱导因子（EMMPRIN，CD147）最初被描述为基质金属蛋白酶（MMPs）表达的诱导剂，因其参与多种免疫疾病而受到关注，因此抗EMMPRIN抗体被视为潜在的治疗药物。鉴于MMPs参与多种疾病状态的发病机制，靶向其上游诱导剂可能是一种有效的治疗策略。此外，现在人们认识到EMMPRIN除了诱导MMPs外还具有多种作用，包括在细胞功能方面，如迁移、黏附、侵袭、能量代谢，以及T细胞活化和增殖。在此，我们综述了关于EMMPRIN在众多免疫/炎症疾病中的已知情况，特别关注其在T细胞生物学中的复杂作用。
